DNA-encoded chemical libraries enable the discovery of potent PSMA-ligands with substantially reduced affinity towards the GCPIII anti-target

Abstract

Prostate-Specific Membrane Antigen (PSMA) is a tumor-associated protein which has been successfully targeted with small organic ligands and with monoclonal antibodies. PluvictoTM is a PSMA-targeted Radio Ligand Therapeutic (RLT) recently...