DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region

Pan, Yang; Wang, Shuo; Liu, Deng-gao; Hua, Zhao; Li, Gang

doi:10.1007/s00784-020-03331-3

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…The CTDIvol in our study was 0.26-21.27 mGy, and the DLP was 4.25-465.42 mGy-cm, both of which were lower than previous studies [18]. Using optimal tube potential may help reduce radiation dose and improve workflow [10].…”

Section: Plos Onecontrasting

confidence: 55%

Variation in tube voltage for pediatric neck 64VCT: Effect on radiation dose and image quality

Chen¹,

Wu²,

Tu³

et al. 2021

PLoS ONE

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Exposure to ionizing radiation can cause cancer, especially in children. In computed tomography (CT), a trade-off exists between the radiation dose and image quality. Few studies have investigated the effect of dose reduction on image quality in pediatric neck CT. We aimed to assess the effect of peak kilovoltage on the radiation dose and image quality in pediatric neck multidetector-row CT. Measurements were made using three phantoms representative of children aged 1, 5, and 10 years, with tube voltages of 80, 100, and 120 kilovoltage peak (kVp); tube current of 10, 40, 80, 120, 150, 200, and 250 mA; and exposure time = 0.5 s (pitch, 0.984:1). Radiation dose estimates were derived from the dose-length product with a 64-multidetector-row CT scanner. Images obtained from the control protocol (120 kVp) were compared with the 80- and 100-kVp protocols. The effective dose (ED) was determined for each protocol and compared with the 120-kVp protocol. Quantitative analysis entailed noise measurements by recording the standard deviation of attenuation for a circular 1-cm2 region of interest placed on homogeneous soft tissue structures in the phantom. The mean noise of the various kVp protocols was compared using the unpaired Student t-test. Reduction of ED was 37.58% and 68.58% for neck CT with 100 kVp and 80 kVp, respectively. The image noise level increased with the decrease in peak kilovoltage. Noise values were higher at 80 kVp at all neck levels, but did not increase at 100 kVp, compared to 120 kVp in the three phantoms. The measured noise difference was the greatest at 80 kVp (absolute increases<2.5 HU). The subjective image quality did not differ among the protocols. Thus, reducing voltage from 120 to 80 kVp for neck CT may achieve ED reduction of 68.58%, without compromising image quality.

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Section: Plos Onecontrasting

confidence: 55%

Variation in tube voltage for pediatric neck 64VCT: Effect on radiation dose and image quality

Chen¹,

Wu²,

Tu³

et al. 2021

PLoS ONE

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Low-dose radiation from CT examination induces DNA double-strand breaks and detectable changes of DNA methylation in peripheral blood cells

Wang,

Li,

et al. 2023

International Journal of Radiation Biology

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Cytogenetic Effects in Patients after Computed Tomography Examination

Neronova

Aleksanin

2022

Life

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Millions of people around the world are exposed to low doses of ionizing radiation from diagnostic computed tomography (CT) scans. Currently available data on the potential cancer risk after CT scans are contradictory and therefore demand further investigations. The aim of the current study was to obtain estimations of genome damage after CT scans in 42 non-cancer patients and to conduct a comparison of the results with 22 control subjects. The frequency of dicentric ring chromosomes and chromosome breaks was significantly increased in irradiated patients compared to the controls. The distribution of dicentrics among the cells demonstrated non-Poisson distribution that reflected non-uniform and partial-body radiation exposure. A fraction of patients followed Poisson distribution, which is typical for uniform whole-body exposures. Some patients demonstrated a level of dicentrics similar to the control subjects. The individual variations in the frequency and dicentric distribution suggested complex mechanisms of chromosome aberration induction and elimination that could be associated with individual radiosensitivity, as well as previous diagnostics that used ionizing radiation or the redistribution of small fractions of irradiated lymphocytes within the circulatory pull. In conclusion, CT scans may cause genome damage and possible increases in cancer risk. The introduction of a specific follow-up of such patients, especially in the case of repeated CT scans, is suggested.

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DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region

Cited by 3 publications

References 33 publications

Variation in tube voltage for pediatric neck 64VCT: Effect on radiation dose and image quality

Variation in tube voltage for pediatric neck 64VCT: Effect on radiation dose and image quality

Low-dose radiation from CT examination induces DNA double-strand breaks and detectable changes of DNA methylation in peripheral blood cells

Cytogenetic Effects in Patients after Computed Tomography Examination

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