1995
DOI: 10.1007/bf00195140
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DNA diagnosis of human genetic individuality

Abstract: DNA studies of the human genome have shown polymorphic variation at thousands of sites, defining an absolute genetic uniqueness for each individual. There are many circumstances in which it may be desirable to diagnose this molecular individuality, as for instance, in criminal investigations or paternity testing. Several techniques can be used for this DNA diagnosis and we can choose among them the one that best suits the specific problem at hand. In this review we describe the main methodologies in current us… Show more

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Cited by 13 publications
(8 citation statements)
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“…15). We reasoned that examination of microsatellite markers from the T. cruzi genome should likewise provide genetic information about the parasite.…”
Section: And 7)mentioning
confidence: 99%
“…15). We reasoned that examination of microsatellite markers from the T. cruzi genome should likewise provide genetic information about the parasite.…”
Section: And 7)mentioning
confidence: 99%
“…This insertion is supposed to have happened in an ancestral human Y chromosome in Africa (Hammer 1994). Alu insertions are known to be unique molecular events and there is no known mechanism for reversibility by specific removal (discussed in Pena et al 1995a). Thus, as an initial analytical step, it makes sense to divide the world's Y chromosomes into two large groups, YAP + and YAP- (Fig.…”
Section: Genome Research @ 607mentioning
confidence: 99%
“…Because they are easily studied using PCR-based procedures, microsatellites have become markers of choice for genetic inferences in forensic sciences, paternity testing, molecular ecology, molecular taxonomy, and evolutionary reconstructions [Bowcock et al, 1994;Butler, 2001;Jin and Chakraborty, 1995;Pena et al, 1995;Queller et al, 1993]. To validate the genetic models behind such inferences, it is important to try to understand in detail the mechanisms that cause mutations in microsatellites and the rate at which they occur.…”
Section: Introductionmentioning
confidence: 98%