DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor

Wong, Hao Yun; Demmers, Jeroen; Bezstarosti, Karel; Grootegoed, J. Anton; Brinkmann, Albert O.

doi:10.1016/j.bbapap.2008.11.001

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…DDX5 and DDX17 have roles in transcription regulation that extend beyond the β-catenin pathway. DDX5 and DDX17 are coactivators of estrogen- 115,116 and androgen-dependent transcription, 13,117 and this feature is independent of their helicase activity. Furthermore, this stimulation appears to rely on phosphorylation of DDX5 on S118 by p38 MAP kinase.…”

Section: Ddx5 and Ddx17mentioning

confidence: 99%

Perturbations of RNA helicases in cancer

Robert

Pelletier

2013

WIREs RNA

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Helicases are implicated in most stages of the gene expression pathway, ranging from DNA replication, RNA transcription, splicing, RNA transport, ribosome biogenesis, mRNA translation, RNA storage and decay. These enzymes utilize energy derived from nucleotide triphosphate hydrolysis to remodel ribonucleoprotein complexes, RNA, or DNA and in this manner affect the information content or output of RNA. Several RNA helicases have been implicated in the oncogenic process--either through altered expression levels, mutations, or due to their role in pathways required for tumor initiation, progression, maintenance, or chemosensitivity. The purpose of this review is to highlight those RNA helicases for which there is significant evidence implicating them in cancer biology.

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Section: Ddx5 and Ddx17mentioning

confidence: 99%

Perturbations of RNA helicases in cancer

Robert

Pelletier

2013

WIREs RNA

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“…Recruitment of coactivators and corepressors, as well as chromatin remodeling, promote the induction of AR dependent gene transcription [14]. Specific combinations of co-factors recruited to ARE provide tissue and ligand-specific factors such as prostate specific antigen (PSA) and transmembrane protease expression [15].…”

Section: The Basic Structure Of Ar Gene and Ar Signaling Pathwaymentioning

confidence: 99%

Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer

Cui,

2023

ann urol oncol

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Prostate cancer (Pca) remains the most common malignancy worldwide in men, and the second leading cause of mortality only to lung cancer. Besides surgery, androgen deprivation therapy (ADT) is a major treatment for Pca. However, ADT leads to the inevitable progression of castration-resistant Pca (CRPC). The transition from hormone-dependent Pca (ADPC) to CRPC has been shown to involve reactivation of the androgen receptor (AR) signaling pathway. The evidence become strong that Pca develop adaptive mechanisms for maintaining AR signaling to allow for survival and further evolution. This article mainly reviews the research progress of the mechanism(s) of AR signaling in CRPC and provides scientific basis and new ideas for the diagnosis and treatment of this phenotype.

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“…A number of novel ARinteracting partners have been characterized, with the majority having been identified in the proteomic screen. These proteins include, heat-shock protein 27 (HSP27) [118], DDX5 [119], SAM68 [120], deleted in breast cancer 1 (DBC1) [121], minichromosome maintenance 7 (MCM7) [122], α-actinin 4 (ACTN4) [116], peroxiredin 1 (PRDX1) [123], DEAD-box polypeptide 17 (DDX17) [124], nucleophosim (NPM1) [125], and Ying Yang 1 (YY1) [126]. Furthermore, these findings point to the complexity of the AR-interacting protein unit and suggest it is involved in a number of different pathways that could function as part of a group of interconnected pathways, whose individual compositions alter depending on AR mutational and stimulation status, to generate the appropriate AR biological output.…”

Section: Ar: More Than a Transcription Factormentioning

confidence: 99%

Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic Resistance

Paliouras¹,

Alvarado²,

Trifiro³

2016

Prostate Cancer - Leading-Edge Diagnostic Procedures and Treatments

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The current description of the function of the human androgen receptor "R , as a transcription factor directing androgen responsive gene expression, is limited in scope and thus is unable to account for the varied cellular and physiological transformation observed in the development and progression of prostate cancer CaP . The chapter will focus on four important aspects of "R and CaP investigations a description of "R somatic mutations and the perils of "R-directed therapeutics our characterization of "R protein interactors that have imbued new functional properties for "R linked to prostatic disease review of the advances made and shortcomings of "R mouse models in describing CaP onset and progression and speculate as to the mechanisms by which new mutations can originate and initiate disease onset.

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DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor

Cited by 8 publications

References 37 publications

Perturbations of RNA helicases in cancer

Perturbations of RNA helicases in cancer

Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer

Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic Resistance

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