DNA-decorated carbon nanotube-based FETs as ultrasensitive chemical sensors: Discrimination of homologues, structural isomers, and optical isomers

Khamis, Samuel M.; Jones, Robert A.; Johnson, A. T. Charlie; Preti, George; Kwak, Jae; Gelperin, Alan

doi:10.1063/1.4705394

Cited by 37 publications

(43 citation statements)

References 65 publications

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“…This weak specificity of eNoses is a strength and a requirement, but makes the chiral recognition a really challenging task. The enantioselectivity of eNoses has been assessed for some technologies such as TGS sensors [7] or DNA coated sensors [12,13]. But these results can be statistically unreliable due to datasets which are too small.…”

Section: Introductionmentioning

confidence: 99%

Reliable chiral recognition with an optoelectronic nose

Maho

Herrier²,

Livache³

et al. 2020

Biosensors and Bioelectronics

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Chiral discrimination is a key problem in analytical chemistry. It is generally performed using expensive instruments or highly-specific miniaturized sensors. An electronic nose is a bio-inspired instrument capable after training of discriminating a wide variety of analytes. However, generality is achieved at the cost of specificity which makes chiral recognition a challenging task for this kind of device. Recently, a peptide-based optoelectronic nose which can board up to hundreds of different sensing materials has shown promising results, especially in terms of specificity. In line with these results, we describe here its use for chiral recognition. This challenging task requires care, especially in terms of statistical reliability and experimental confounds. For these reasons, we set up an automatic gas sampling system and recorded data over two long sessions, taking care to exclude possible confounds. Two couples of chiral molecules, namely (R) and (S) Limonene and (R) and (S) Carvone, were tested and several statistical analyses indicate the almost perfect discrimination of their two enantiomers. A method to highlight discriminative sensing materials is also proposed and shows that successful discrimination is likely achieved using just a few peptides.

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Section: Introductionmentioning

confidence: 99%

Reliable chiral recognition with an optoelectronic nose

Maho

Herrier²,

Livache³

et al. 2020

Biosensors and Bioelectronics

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“…Chemical modification of the sensor surface influences the interaction strength between the sensor and analyte molecules and thereby improve the performance of the sensing device in terms of sensitivity and selectivity. Surface functionalization has been investigated with many different approaches including polymer coatings, applying metallic catalysts, atomic doping and coating with single stranded DNA (ssDNA) [1][2][3][4][5][6][7][8][9][10]. Although each individual sensor has a characteristic response, such data from an isolated sensor would be useful only in a controlled environment that contained a single, known gas or binary mixture.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of vapor mixture with chemical sensor arrays

et al. 2015

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Arrays of partially selective chemical sensors have been the focus of extensive research over the past decades because of their potential for widespread application in ambient air monitoring, health and safety, and biomedical diagnostics. Especially, vapor sensor arrays based on functionalized nanomaterials have shown great promise with their high sensitivity by dimensionality and outstanding electronic properties. Here, we introduce experiments where individual vapors and mixtures of them are examined by different chemical sensor arrays. The collected data from those sensor arrays are further analyzed by a principal component analysis (PCA) and targeted vapors are recognized based on prepared database.

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“…It seems one-dimensional (1D) nano-materials are attractive candidates not only for the formation of conductive channels but also for the providing high effective area for the immobilization of bio-molecules [12][13][14][15][16][17]. Based on the mentioned idea it is possible detect very low concentrations of various analytes using a FET constructed by 1D nano materials which its channel region has been functionalized with the biomolecule such as enzyme or antibody [18][19][20]. The binding of the analyte to the functionalized channel of the mentioned FET causes a change in the gate electric field and consequently change in I DS .…”

Section: Introductionmentioning

confidence: 99%