DNA damaging potential of Ganoderma lucidum extracts

Gurovic, Maria Soledad Vela; Viceconte, Fátima Regina; Pereyra, Marcelo Tomas; Bidegain, Maximiliano Andrés; Cubitto, María Amelia

doi:10.1016/j.jep.2018.02.005

Cited by 21 publications

(15 citation statements)

References 26 publications

(32 reference statements)

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“…No animal mortality was reported either (Smina et al, 2011). When compared to doxorubicin (a typical DNA intercalating agent used in chemotherapy), G. lucidum extracts were shown to act indirectly on DNA, thus adding more assurance to its safety (Gurovic et al, 2018).…”

Section: Safety Toxicity and Side Effects Of G Lucidummentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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Section: Safety Toxicity and Side Effects Of G Lucidummentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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“…lucidum pills can promote the healing of chronic gastric ulcers induced by ethanol and significantly improve gastric mucosal injury [ 14 ]. Triterpenoids are the most promising candidates for clinical drugs whose natural compounds have pharmacological activities [ 15 ]. Ganoderic acid A (GAA), as the most important component of triterpenoids, has relatively good anti-inflammatory, antitumor, and other pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia

Yang

Li²,

Zhou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The therapeutic effect of drugs for functional dyspepsia (FD) is still limited. Ganoderic acid A (GAA) has anti-inflammatory and cellular protective activities. The aim of this study is to explore the therapeutic effect of GAA on FD. Methods. The FD rat model was established via tail damping and forced exercise fatigue. The gastric emptying rate and intestinal propulsion rate of the rats in each group were then detected, and the pathological damage of gastric antrum and duodenum tissues was observed by hematoxylin-eosin (HE) staining. An enzyme-linked immunosorbent assay (ELISA) was conducted to determine the levels of motilin (MTL), vasoactive intestinal peptide (VIP), leptin, gastrin (GAS), calcitonin gene-related peptide (CGRP), and somatostatin (SS) in plasma, and Western blot was used to detect the protein expression levels of occludin, zonula occluden-1 (ZO-1), and junctional adhesion molecule-1 (JAM-1) in the duodenal tissue. Results. Treatment with GAA significantly raised the gastric emptying rate and intestinal propulsion rate of FD rats and histologically alleviated the gastric and duodenal damage. Meanwhile, GAA positively regulated the secretion of brain-gut proteins, such as upregulation of MTL, GAS, and SS and downregulation of VIP, leptin, and CGRP. In addition, GAA treatment increased the protein expression levels of occludin, ZO-1, and JAM-1 in the duodenal tissue of the FD rats. Conclusion. GAA may exhibit protective effects on FD by regulating the secretion of brain-gut peptide, protecting the intestinal barrier and improving gastrointestinal motility.

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“…As previously mentioned, the genus Ganoderma belongs to the sister clade of F. rugosa. In the studies by Gurovic et al ( 2018 ), the presence of fatty acids in G. lucidum caused weak, indirect damaging effects on the prokaryotic cell, which was attributed to an indirect damage of the DNA. Thus, fatty acids should be considered as active components of G. lucidum .…”

Section: Discussionmentioning

confidence: 98%

First report of chemical composition and cytotoxicity evaluation of Foraminispora rugosa basidiomata from Brazil

et al. 2022

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Background Foraminispora rugosa is a species reported from Brazil, Venezuela, French Guiana, Costa Rica and Cuba. It is a basidiomycete in the Ganodermataceae family. In this study, both chemical composition and cytotoxicity of the ethanolic extract of F. rugosa were investigated for the first time. Results Phylogenetic analysis confirmed the identification of the specimens, and the results of cytotoxicity assays showed that at concentrations of 7.8–500.0 µg/mL the ethanolic extract displayed weak cytotoxicity against the tested cell lines. Five oxylipins were identified by ultra high performance liquid chromatography coupled with quadrupole time-of-flight and mass spectrometry (UHPLC-QTOF–MS). Conclusions This study provides new insights into the current knowledge of bioactive compounds produced by macrofungi, and provides data for future biological assays with relative selectivity and safety.

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DNA damaging potential of Ganoderma lucidum extracts

Cited by 21 publications

References 26 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia

First report of chemical composition and cytotoxicity evaluation of Foraminispora rugosa basidiomata from Brazil

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