DNA Damage, Mutagenesis and Cancer

Basu, Ashis K.

doi:10.3390/ijms19040970

Cited by 346 publications

(242 citation statements)

References 92 publications

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“…Nevertheless, the development of visible emitting light sources, such as lasers and LEDs for 3D printing or medical applications, requires the design of novel photoinitiating systems effective in the visible spectral range and especially in the 400–500 nm region . Moreover, UV light is also well known to cause skin and eye damage and can not be used for the dental field.…”

Section: Introductionmentioning

confidence: 99%

Silyl glyoxylates as high‐performance photoinitiators for cationic and hybrid polymerizations: Towards better polymer mechanical properties

Kirschner

Bouzrati-Zerelli

Fouassier

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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Silyl glyoxylates are proposed here as high‐performance photoinitiators (PIs) for the hybrid polymerization of cationic and radical monomers. Recently, silyl glyoxylates were reported as a new class of high‐performance Type I photoinitiators for free radical polymerization under air upon exposure to different near‐UV and blue LEDs. In this article, we report this new class of photoinitiators to initiate cationic polymerization in combination with an iodonium salt. This system can also be used to initiate simultaneously free radical and cationic polymerizations, for example, for the free radical/cationic hybrid polymerization and for the synthesis of interpenetrating polymer networks. The system silyl glyoxylate/iodonium exhibits excellent polymerization performances and exceptional bleaching properties compared to other well established photoinitiators (e.g., camphorquinone). Furthermore, a hybrid monomer is also introduced in this article (2‐vinyloxyethoxyethyl methacrylate [VEEM]) leading to a huge improvement of the mechanical properties of the final polymer through hybrid polymerization. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1420–1429

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Section: Introductionmentioning

confidence: 99%

Silyl glyoxylates as high‐performance photoinitiators for cationic and hybrid polymerizations: Towards better polymer mechanical properties

Kirschner

Bouzrati-Zerelli

Fouassier

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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“…In cells, production of reactive oxygen species (ROS) and inflammation have been recognized to cause DNA lesions [3]. DNA damage has been found to be involved in aging and development of common diseases including cancer, atherosclerosis, metabolic syndrome [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women

Włodarczyk

Ciebiera²

2019

Mol Biol Rep

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Obesity is associated with inflammation, which can disturb genome stability. Tumor necrosis factor (TNF-α) polymorphism was found to affect TNF-α protein production and inflammation. Therefore, the present study illustrates the relationship between TNF-α polymorphism, the degree of inflammation assessed by serum high sensitivity C-reactive protein concentration (CRP-hs) and basal DNA damage in patients with obesity (BMI 30-34.9 kg/m 2) and control subjects with proper body mass (BMI < 25 kg/m 2). A total of 115 participants (75 obese premenopausal women; and 40 age-, and gender-matched controls) were included. Biochemical parameters (serum concentrations of total-cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, glucose, apolipoprotein AI, CRP-hs) and endogenous DNA damage (determined by comet assay) were measured. TNF-α G-308A polymorphism (rs1800629) was analyzed by PCR-RFLP (PCR-restriction fragments length polymorphism). An effect of TNF-α genotype on serum CRP-hs concentration was noted (p = 0.031). In general, carriers of the rare A allele of the TNF-α G-308A polymorphism had significantly lower endogenous DNA damage and serum CRPhs concentrations than GG homozygotes, however, the protective effect of the A allele was especially visible in non-obese women. Serum CRP-hs concentrations and levels of DNA damage (% DNA in tail) were significantly higher in obese than in controls (p = 0.001 and p < 0.0001, respectively). The adjusted multiple linear regression analyses revealed a significant, independent impact of obesity on DNA damage (p = 0.00000) and no effect of other covariates i.e. age, TNF-α genotype and serum CRP-hs concentration. Our study showed that obesity has a significant impact on the levels of endogenous DNA damage. Obesity abolished the protective effect of A allele of the TNF-α G-308A polymorphism on DNA damage and on inflammation development observed in non-obese A allele carriers.

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“…The downregulated genes were mainly overrepresented in cell division, nuclear division, DNA replication and second-messenger-mediated signaling, and the upregulated genes were mainly involved in cell cycle process, DNA metabolic process, the transforming growth factor (TGF)-β signaling pathway and angiogenesis. Previous articles have revealed that dysregulation of angiogenesis and activation of the TGF-β signaling pathway are associated with the carcinogenesis and progression of lung adenocarcinoma (36)(37)(38). In addition, DNA damage and metabolic process abnormalities often play a significant role in cell cycle regulation dysfunction and are associated with malignant tumors (39).…”

Section: Discussionmentioning

confidence: 99%

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples

et al. 2020

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Lung adenocarcinoma is one of the most common malignant tumors worldwide. Although efforts have been made to clarify its pathology, the underlying molecular mechanisms of lung adenocarcinoma are still not clear. The microarray datasets GSE75037, GSE63459 and GSE32863 were downloaded from the Gene Expression Omnibus (GEO) database to identify biomarkers for effective lung adenocarcinoma diagnosis and therapy. The differentially expressed genes (DEGs) were identified by GEO2R, and function enrichment analyses were conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). The STRING database and Cytoscape software were used to construct and analyze the protein-protein interaction network (PPI). We identified 376 DEGs, consisting of 83 upregulated genes and 293 downregulated genes. Functional and pathway enrichment showed that the DEGs were mainly focused on regulation of cell proliferation, the transforming growth factor β receptor signaling pathway, cell adhesion, biological adhesion, and responses to hormone stimulus. Sixteen hub genes were identified and biological process analysis showed that these 16 hub genes were mainly involved in the M phase, cell cycle phases, the mitotic cell cycle, and nuclear division. We further confirmed the two genes with the highest node degree, DNA topoisomerase IIα (TOP2A) and aurora kinase A (AURKA), in lung adenocarcinoma cell lines and human samples. Both these genes were upregulated and associated with larger tumor size. Upregulation of AURKA in particular, was associated with lymphatic metastasis. In summary, identification of the DEGs and hub genes in our research enables us to elaborate the molecular mechanisms underlying the genesis and progression of lung adenocarcinoma and identify potential targets for the diagnosis and treatment of lung adenocarcinoma.

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DNA Damage, Mutagenesis and Cancer

Cited by 346 publications

References 92 publications

Silyl glyoxylates as high‐performance photoinitiators for cationic and hybrid polymerizations: Towards better polymer mechanical properties

Silyl glyoxylates as high‐performance photoinitiators for cationic and hybrid polymerizations: Towards better polymer mechanical properties

TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples

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