2016
DOI: 10.18632/aging.100890
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Abstract: The aging process is accompanied by an accumulation of cellular damage, which compromises the viability and function of cells and tissues. We aim to further explore the association between in vitro DNA damage markers and the chronological age of the donor, as well as long-lived family membership and presence of cardiovascular diseases. Therefore, numbers of 53BP1 foci, telomere-associated foci (TAF) and micronuclei were measured in cultured dermal fibroblasts obtained from three age groups of donors (mean age … Show more

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Cited by 16 publications
(16 citation statements)
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References 38 publications
(47 reference statements)
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“…There was no significant difference in terms of cellular senescence status between NHDFs derived from young and old donors. These results are consistent with previous observations that the replicative senescence of fibroblasts in culture shows no correlation with donor age …”
Section: Resultssupporting
confidence: 93%
“…There was no significant difference in terms of cellular senescence status between NHDFs derived from young and old donors. These results are consistent with previous observations that the replicative senescence of fibroblasts in culture shows no correlation with donor age …”
Section: Resultssupporting
confidence: 93%
“…Dysfunctional telomeres resemble DSBs and they have been observed during ageing, cancer and a number of medical conditions11121314151617. Apart from telomeric repeat-containing RNA (TERRA), a non-coding UUAGGG-rich transcript starting from promoters located in the subtelomeric region1819, in mammals no other transcripts at telomeres have been characterized so far.…”
mentioning
confidence: 99%
“…Although the age span of the patients was not great and is sometimes used as a single age category in aging studies [18, 19], a remarkable inter-individual variability in the clonogenic capacity of their skin fibroblasts was found as evident from the results of their clonogenic analysis (Table 1). Indeed, the variability was demonstrated both in ECO-f (from 9.7 up to 61.0%) and in the fractions of each colony phenotype.…”
Section: Resultsmentioning
confidence: 99%