DNA damage, copper and lead associates with cognitive function among older adults

Meramat, Asheila; Rajab, Nor Fadilah; Shahar, Suzana; Sharif, Razinah

doi:10.1007/s12603-016-0759-1

Cited by 31 publications

(23 citation statements)

References 42 publications

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“…Ingles et al43 reported that frail older adults displayed more oxidative damage than the non-frail participants. Moreover, several studies have reported the contribution of high plasma MDA levels in the neurodegenerative process of dementia 44,45. Oxidative stress may also increase the rate of telomere shortening by site-specific DNA damage to the telomere sequence 46.…”

Section: Discussionmentioning

confidence: 99%

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

Rivan¹,

Shahar²,

Rajab³

et al. 2019

CIA

115

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Purpose This study was aimed at determining the presence of cognitive frailty and its associated factors among community-dwelling older adults from the “LRGS-Towards Useful Aging (TUA)” longitudinal study. Patients and methods The available data related to cognitive frailty among a sub-sample of older adults aged 60 years and above (n=815) from two states in Malaysia were analysed. In the LRGS-TUA study, a comprehensive interview-based questionnaire was administered to obtain the socio-demographic information of the participants, followed by assessments to examine the cognitive function, functional status, dietary intake, lifestyle, psychosocial status and biomarkers associated with cognitive frailty. The factors associated with cognitive frailty were assessed using a bivariate logistic regression (BLR). Results The majority of the older adults were categorized as robust (68.4%), followed by cognitively pre-frail (37.4%) and cognitively frail (2.2%). The data on the cognitively frail and pre-frail groups were combined for comparison with the robust group. A hierarchical BLR indicated that advancing age (OR=1.04, 95% CI:1.01–1.08, p <0.05) and depression (OR=1.49, 95% CI:1.34–1.65, p <0.001) scored lower on the Activity of Daily Living (ADL) scale (OR=0.98, 95% CI:0.96–0.99, p <0.05), while low social support (OR=0.98, 95% CI:0.97–0.99, p <0.05) and low niacin intake (OR=0.94, 95% CI:0.89–0.99, p <0.05) were found to be significant factors for cognitive frailty. Higher oxidative stress (MDA) and lower telomerase activity were also associated with cognitive frailty ( p <0.05). Conclusion Older age, a lower niacin intake, lack of social support, depression and lower functional status were identified as significant factors associated with cognitive frailty among older Malaysian adults. MDA and telomerase activity can be used as potential biomarkers for the identification of cognitive frailty.

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Section: Discussionmentioning

confidence: 99%

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

Rivan¹,

Shahar²,

Rajab³

et al. 2019

CIA

115

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“…DNA damage was determined using alkaline comet assay as previously described [ 20 ]. Briefly, 50 μL of whole blood were embedded in 70 μL of agarose gel (Sigma, USA) on frosted slides prior to lysis in denaturing buffer and electrophoresis (300 mA, 25 V).…”

Section: Methodsmentioning

confidence: 99%

Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

et al. 2020

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Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group’s subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.

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“…Interestingly, a study by Lovell and Markesbery [11] showed an elevated level of 8-OHG, 8-OHA, and 5, 6-diamino-5-formamidopyrimidine in both nuclear and mtDNA isolated from brain regions of mild cognitive impaired subjects, the earliest clinical manifestation of AD. Meramat et al [33] showed that a total of 62.1% of subjects above 60 years old had cognitive impairment, and among them, there are significantly higher levels of MDA and DNA damage as compared to the group with normal cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Changes and Cognitive Function Decline in Aging Rats

Rudin

Makpol

Ngah

et al. 2019

Asian J Pharm Clin Res

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Objective: This study aims to show that impairment of cognitive function occurred during aging is related to increased oxidative stress. Methods: A total of 36 Sprague Dawley rats were divided into four groups: Young (3 months), middle (14 months), and old age groups (18 and 23 months). Rats were killed and blood was collected for the measurement of oxidative stress which includes deoxyribonucleic acid (DNA) damage and lipid peroxidation (malondialdehyde [MDA] levels). Cognitive function of rats was measured through open-field experiments, Morris water maze (MWM), and object identification. Results: Increased DNA damage and MDA levels were found in middle age and old rats compared to young rats (3 months old, p<0.05). There was an increase in anxiety with age as indicated by the increased production of fecal boli and decreased activity of grooming and rearing. For the navigation test, older rats took a long time to search for the hidden platform compared to young rats. In the probe test (spatial memory test 24 h after the last training), the middle- and old-age groups spent less time at the quadrant compared to the young age group. Conclusion: There is a decline in cognitive function with increased oxidative stress in aging rats.

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DNA damage, copper and lead associates with cognitive function among older adults

Abstract: High levels of lead and copper can lead to increase in oxidative stress levels and are associated with DNA damage that eventually could be associated with cognitive decline.

Cited by 31 publications

References 42 publications

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

Oxidative Changes and Cognitive Function Decline in Aging Rats

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