DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace

Fracasso, Maria Enrica; Doria, Denise; Franceschetti, Paola; Perbellini, Luigi; Romeo, Luciano

doi:10.1016/j.toxlet.2006.09.003

Cited by 56 publications

(31 citation statements)

References 47 publications

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“…In the present study, passive subjects were grouped based on exposure period, in a similar study has been carried out among white-collar active smokers and passive smokers (non-and ex-smokers) at workplace (Fracasso et al 2006). A direct physical measurement of exposure to tobacco smoke would reduce potential problems associated with self-report, such as inaccurate recall, underreporting, and misinterpretation of questions.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Chromosome Aberrations in Subjects Exposed to Environmental Tobacco Smoke in Tamilnadu, India

Vellingiri

Kumar

Suresh

et al. 2008

Bull Environ Contam Toxicol

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Numerous expert panels have concluded that there is sufficient evidence to classify involuntary smoking (or passive smoking) as carcinogenic to humans. The aim of this study is to establish whether passive smoking increases the frequency of chromosomal aberrations (CA) in peripheral blood lymphocytes compared to controls in Tamil Nadu, India. In the present study, CA increased with an increase in environmental tobacco smoke (ETS) and active smoke exposure period in passive smokers quantified on the basis of serum cotinine levels. The passive subjects were compared with healthy normal controls to validate the results. In conclusion, these data are compatible with the current knowledge on the mechanisms of carcinogenesis of tobacco-related cancers, occurring not only in active smokers but with a high biological plausibility also in passive smokers.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Chromosome Aberrations in Subjects Exposed to Environmental Tobacco Smoke in Tamilnadu, India

Vellingiri

Kumar

Suresh

et al. 2008

Bull Environ Contam Toxicol

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“…Smoking also influences DNA damage and repair capacity (51). Although a few small studies have reported associations between levels of expression of proteins involved in DNA repair and survival in head and neck cancer patients (52)(53)(54), none appear to have explored the influence of smoking on these relationships.…”

Section: Other Potential Mechanismsmentioning

confidence: 99%

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Sharp

McDevitt

Carsin

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Some studies suggest smoking may result in poorer clinical outcomes in head and neck cancer, but the evidence is heterogeneous and some of it is poor quality. In a large, population-based, study we investigated: (i) whether smoking at diagnosis is an independent prognostic factor for cancer-specific survival in head and neck cancer; and (ii) whether the association varies by site and treatment.Methods: Head and neck cancers (ICD10 C01-C14, and C30-32) diagnosed from 1994 to 2009 were abstracted from the National Cancer Registry Ireland, and classified by smoking status at diagnosis. Follow-up was for 5 years or until December 31, 2010. Multivariate Cox proportional hazards models were used to compare cancerspecific death rates in current, ex-, and never smokers. Subgroup analyses by site and treatment were conducted.Results: In total, 5,652 head and neck cancers were included. At diagnosis, 24% were never smokers, 20% exsmokers, and 56% current smokers. Compared with never smokers, current smokers had a significantly raised death rate from cancer [multivariate HR, 1.36; 95% confidence interval (CI), 1.21-1.53]. The association was similar after restriction to squamous cell tumors. A significantly increased cancer-related death rate was seen for current smokers with oral cavity, pharyngeal, and laryngeal cancers. The association was stronger in surgically treated patients [HR, 1.49; 95% CI, 1.25-1.79; P(interaction) ¼ 0.01]. Neither radiotherapy nor chemotherapy modified the effect of smoking.Conclusions: Patients with head and neck cancer who smoke at diagnosis have a significantly increased cancer death rate.Impact: Greater efforts are needed to encourage and support smoking cessation in those at risk of, and diagnosed with, head and neck cancer. Cancer Epidemiol Biomarkers Prev; 23(11); 2579-90. Ó2014 AACR.

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“…18,22,24,[38][39][40][41] According to that fact, scientists revealed that using the standard alkaline comet assay it is possible to detect damages at radiation doses from 5 cGy to 10 cGy 42,43 and in some adapted experimental conditions (e.g. addition of the Fpg enzyme) it is possible to detect damages even at radiation doses of 0.6 cGy.…”

Section: Comet Assay and Fpg-modified Comet Assaymentioning

confidence: 99%

Usage of the standard and modified comet assay in assessment of DNA damage in human lymphocytes after exposure to ionizing radiation

Mikloš¹,

Gajski²,

Garaj‐Vrhovac³

2009

Radiology and Oncology

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DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace

Cited by 56 publications

References 47 publications

Evaluation of Chromosome Aberrations in Subjects Exposed to Environmental Tobacco Smoke in Tamilnadu, India

Evaluation of Chromosome Aberrations in Subjects Exposed to Environmental Tobacco Smoke in Tamilnadu, India

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Usage of the standard and modified comet assay in assessment of DNA damage in human lymphocytes after exposure to ionizing radiation

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