DNA damage and oxidative stress in long-lived aquatic organisms

Wojtczyk-Miaskowska, A.; Schlichtholz, Beata

doi:10.1016/j.dnarep.2018.07.003

Cited by 17 publications

(9 citation statements)

References 144 publications

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“…Thus, it may impair fish health, antioxidant and immune responses. Excessive ROS can cause various tissue damages of fish, such as protein oxidation, lipid peroxidation and DNA damage (Wojtczyk‐Miaskowska & Schlichtholz, 2018). In the present study, fish farmed at HSD group exhibited lower hepatic SOD and CAT activities on 120 days.…”

Section: Discussionmentioning

confidence: 99%

Effects of stocking density on growth, serum parameters, antioxidant status, liver and intestine histology and gene expression of largemouth bass ( Micropterus salmoides ) farmed in the in‐pond raceway system

Wang

Nie

et al. 2020

Aquac Res

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In China, the in‐pond raceway system (IPRS) recirculating culture is a new model of freshwater aquaculture. A 120‐day feeding study was carried out to evaluate the influence of stocking density on growth, digestive enzymes activity, serum parameters, antioxidant status, liver and intestine histology and gene expression of HSP70 and Cu/Zn‐SOD of largemouth bass farmed in IPRS. Largemouth bass, Micropterus salmoides (initial body weight, 4.50 ± 0.23 g), were randomly farmed in nine raceways stocked at three stocking densities of 0.2 (LSD), 0.4 (MSD) and 0.6 (HSD) kg/m3, and sampled at 30, 60, 90 and 120 days. The results showed that body weight, specific growth rate and weight gain of fish farmed at MSD group were higher than that farmed at LSD and HSD treatments on 30 days (p < 0.05), while fish farmed at MSD and HSD treatments had significantly lower growth than those farmed at LSD groups on 90 and 120 days (p < 0.05). There were no significant differences in serum cortisol, glucose and triglyceride levels among three groups on 30, 60 and 90 days (p > 0.05), whereas fish farmed at HSD group had significant higher values than that farmed at LSD group on 120 day (p < 0.05). There were no significant differences in serum lysozyme level on day 30, while it decreased with increasing stocking densities on after day 60. Fish reared at LSD group had significantly higher SOD activities than those farmed at MSD and HSD treatments, and had significantly higher CAT activities than those farmed at HSD group on 120 day (p < 0.05). MDA level increased with increasing stocking density on days 60, 90 and 120 (p < 0.05). Fish farmed at HSD group had significantly higher liver HSP70 mRNA levels on days 90 and 120 (p < 0.05). Cu/Zn‐SOD mRNA levels showed a downward trend. No significant difference was observed on liver and intestine histology (p > 0.05). In conclusion, largemouth bass farmed at 0.4 kg/m3 had better growth and health status before days 30. After that, fish farmed at higher stocking densities in IPRS would inhibit growth and reduce immune function.

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Section: Discussionmentioning

confidence: 99%

Effects of stocking density on growth, serum parameters, antioxidant status, liver and intestine histology and gene expression of largemouth bass ( Micropterus salmoides ) farmed in the in‐pond raceway system

Wang

Nie

et al. 2020

Aquac Res

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“…Hormetic priming describes the beneficial effects of pre-exposure enhancing the ability to cope with subsequent encounters of similar or higher levels of stress later in life, as opposed to individuals without previous experience or primed under severe stress (Costantini, 2014). Mild oxidative stress presents a common source of hormetic priming (Costantini, 2014) and is a hypothesized driver of longevity (Ristow and Schmeisser, 2014;Wojtczyk-Miaskowska and Schlichtholz, 2018). For example, early-life exposure to moderate oxidative stress in the Caribbean fruit fly Anastrepha suspensa and zebra finch Taeniopygia guttata decreases cellular damage and increases proteomic defense, energy assimilation and survival under a subsequent stress encounter during adulthood (Costantini et al, 2012;Visser et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Repeat exposure to hypercapnic seawater modifies growth and oxidative status in a tolerant burrowing clam

Gurr

Trigg

Vadopalas

et al. 2021

Journal of Experimental Biology

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Whereas low levels of thermal stress, irradiance, and dietary restriction can have beneficial effects for many taxa, stress acclimation remains understudied in marine invertebrates, despite being threatened by climate change stressors such as ocean acidification. To test for life-stage and stress-intensity dependence in eliciting enhanced tolerance under subsequent stress encounters, we initially conditioned pediveliger Pacific geoduck (Panopea generosa) larvae to (i) ambient and moderately elevated pCO2 (920 µatm and 2800 µatm, respectively) for 110 days, (ii) secondarily applied a 7-day exposure to ambient, moderate, and severely elevated pCO2 (750 µatm, 2800 µatm, and 4900 µatm, respectively), followed by 7 days in ambient conditions, and (iii) implemented a 7-day third exposure to ambient (970 µatm) and moderate pCO2 (3000 µatm). Initial conditioning to moderate pCO2 stress followed by second and third exposure to severe and moderate pCO2 stress increased respiration rate, organic biomass, and shell size suggesting a stress-intensity-dependent effect on energetics. Additionally, stress-acclimated clams had lower antioxidant capacity compared to clams under ambient conditions, supporting the hypothesis that stress over postlarval-to-juvenile development affects oxidative status later in life. Time series and stress intensity-specific approaches can reveal life-stages and magnitudes of exposure, respectively, that may elicit beneficial phenotypic variation.

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“…Similarly, our results showed that inhibition of survivin caused the increase of reactive oxygen species (ROS) level; therefore, high levels of ROS might be one of the causes that contribute to early embryonic dysplasia after inhibition of survivin activity. It is well known that ROS could induce DNA damage and consequently, a DNA damage response (DDR) [33,34]. ROS could induce double-strand DNA breaks (DSBs) and oxidative clustered DNA lesions (OCDLs) [35].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development

Pan

et al. 2020

Cell Cycle

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The early embryonic development is important for the subsequent embryo implantation, and any defects in this process can lead to embryonic aneuploidy, which causes miscarriage and birth defects. Survivin is the member of inhibitor of apoptosis protein (IAP) family, and it is also an essential subunit of chromosomal passenger complex (CPC), which regulates both apoptosis and cell cycle control in many models. However, the roles of survivin in mouse early embryos remain unclear. In the present study, we showed that survivin activity was essential for mouse early embryo development. Our results showed that survivin mainly accumulated at chromosomes at metaphase stage and located at the spindle midzone at anaphase and telophase stages during the first cleavage. Loss of survivin activity led to the failure of cleavage in early mouse embryos. Further analysis indicated that survivin involved into spindle organization and chromosome alignment. Moreover, inhibition of survivin induced oxidative stress and DNA damage, showing with the increase of ROS level, the positive γH2A signal, and the increase of Rad51 level. We also observed the occurrence of autophagy and apoptosis in the survivin-inhibited embryos. In summary, our study suggested that survivin was a critical regulator for early embryo development through its regulation on spindle organization, chromosome alignment, and DNA damage.

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DNA damage and oxidative stress in long-lived aquatic organisms

Cited by 17 publications

References 144 publications

Effects of stocking density on growth, serum parameters, antioxidant status, liver and intestine histology and gene expression of largemouth bass ( Micropterus salmoides ) farmed in the in‐pond raceway system

Effects of stocking density on growth, serum parameters, antioxidant status, liver and intestine histology and gene expression of largemouth bass ( Micropterus salmoides ) farmed in the in‐pond raceway system

Repeat exposure to hypercapnic seawater modifies growth and oxidative status in a tolerant burrowing clam

Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development

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