DNA damage and cholinesterase activity in occupational workers exposed to pesticides

Singh, Satyender; Kumar, Vivek; Thakur, Sachin; Banerjee, Basu Dev; Chandna, Sudhir; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir; Ichhpujani, Rattan; Rai, Arvind

doi:10.1016/j.etap.2010.11.005

Cited by 101 publications

(53 citation statements)

References 47 publications

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“…23,[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] This list is not exhaustive but highlights both established markers of pesticide exposure (such as cholinesterase activity) and emerging biomarkers (such as the ''challenge assay,'' which assesses the DNA repair capacity of cells). It should be noted that most of these biomarkers are not used in the clinic at present; however, they have usefulness in research studies that aim to determine the etiology of cancers that have been linked to agrochemical exposure.…”

Section: Biomarkers Relevant To Pesticide-induced Cancersmentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

287

209

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Biomarkers Relevant To Pesticide-induced Cancersmentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

287

209

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“…[40][41][42][43][44] For instance, in a pesticide -exposed population in India, significant decrease in cholinesterase level was reported. 45 Several other studies have also suggested a decrease in BChE level in response to exposure to organophosphates. 46,47 Similarly, in other parts of the developing world, including Mexico, Kenya, and Bangladesh, similar findings have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…46,47 Similarly, in other parts of the developing world, including Mexico, Kenya, and Bangladesh, similar findings have been reported. 45,48,49 Varying responses of the populations exposed to insecticides by varying degree indicate that the impact rendered on part of these insecticides depends on a number of factors, such as the duration of exposure, the use of protective measures, etc.…”

Section: Discussionmentioning

confidence: 99%

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

Shahzad¹,

Yaqub²,

Shaukat³

et al. 2016

Annals KEMU

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Background: In recent decades, use of pesticides in agricultural practices has posed threat to human population. Objectives: Present research was designed to explore the adverse effects of insecticides on 339 individuals (study group farmers n = 256 and control n = 83) selected from 62 different sites of central Punjab. The sample was matched on socio-economic status and age. Methodology: A structured questionnaire was used to

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“…Mothers who are less able to detoxify organophosphorus pesticides because of low paraoxonase enzyme activity are at increased risk for having children with ASD and ADHD. 52,53 Studies by Singh et al 54,55 provide evidence that individuals with more susceptible genotypes who are exposed to organophosphorus pesticides exhibit greater DNA damage. Thus, "dose plus host" determines toxicity.…”

Section: Discussionmentioning

confidence: 99%

Maternal Chemical and Drug Intolerances: Potential Risk Factors for Autism and Attention Deficit Hyperactivity Disorder (ADHD)

Heilbrun

Palmer

Jaén

et al. 2015

The Journal of the American Board of Family Medicine

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Purpose: The aim of this study was to assess whether chemically intolerant women are at greater risk for having a child with autism spectrum disorders (ASD) or attention deficit hyperactivity disorder (ADHD).Methods: We conducted a case-control study of chemical intolerance among mothers of children with ASD (n ‫؍‬ 282) or ADHD (n ‫؍‬ 258) and children without these disorders (n ‫؍‬ 154). Mothers participated in an online survey consisting of a validated chemical intolerance screening instrument, the Quick Environmental Exposure and Sensitivity Inventory (QEESI). Cases and controls were characterized by parental report of a professional diagnosis. We used a one-way, unbalanced analysis of variance to compare means across the 3 groups.Results: Both mothers of children with ASD or ADHD had significantly higher mean chemical intolerance scores than did mothers of controls, and they were more likely to report adverse reactions to drugs. Chemically intolerant mothers were 3 times more likely (odds ratio, 3.01; 95% confidence interval, 1.50 -6.02) to report having a child with autism or 2.3 times more likely (odds ratio, 2.3; 95% confidence interval, 1.12-5.04) to report a child with ADHD. Relative to controls, these mothers report their children are more prone to allergies (P < .02), have strong food preferences or cravings (P < .003), and have greater sensitivity to noxious odors (P < .04). Conclusion

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DNA damage and cholinesterase activity in occupational workers exposed to pesticides

Cited by 101 publications

References 47 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

Maternal Chemical and Drug Intolerances: Potential Risk Factors for Autism and Attention Deficit Hyperactivity Disorder (ADHD)

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