DNA copy number profiling in esophageal Barrett adenocarcinoma:

Varis, Asta; Puolakkainen, Pauli; Savolainen, H.; Kokkola, Arto; Salo, Jarmo A.; Nieminen, Outi; Nordling, Stig; Knuutila, Sakari

doi:10.1016/s0165-4608(00)00423-4

Cited by 39 publications

(9 citation statements)

References 26 publications

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“…Analyses of a large series of tumor samples using comparative genomic hybridization (CGH) have revealed not only characteristic recurrent chromosomal gains and losses in adenocarcinomas (malignant tumors arising from glandular epithelium) compared to squamous cell carcinomas (malignant tumors arising from squamous epithelium) from different sites of origin (Hermsen et al, , 2002Meijer et al, 1998;Grieken et al, 2000), but also a higher frequency of centromeric breakage and imbalances involving whole chromosome arms in squamous cell carcinomas compared to adenocarcinomas (Hermsen et al, 1996;Petersen et al, 1997;Luk et al, 2001;Pei et al, 2001;Varis et al, 2001;Weiss et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas

et al. 2005

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Structural chromosomal aberrations are common in epithelial tumors. Here, we compared the location of centromeric breaks associated with whole arm translocations in seven adenocarcinoma cell lines and nine squamous cell carcinoma cell lines using SKY, microarray-based comparative genomic hybridization (array CGH) and fluorescence in situ hybridization (FISH). Whole arm translocations were more frequent in squamous cell carcinomas (112 in nine cell lines and nine in one short-term culture) than in adenocarcinomas (13 in seven cases) and most often resulted in copy number alterations. Array CGH analysis demonstrated that in all squamous cell carcinomas and in most adenocarcinomas, the breakpoints of unbalanced whole arm translocations occurred between the two clones on the array flanking the centromeres. However, FISH with centromeric probes revealed that in squamous cell carcinomas, the marker chromosomes with whole arm translocations contained centromeres comprised of material from both participating chromosomes, while in adenocarcinomas centromeric material from only one of the chromosomes was present. These observations suggest that different mechanisms of centromeric instability underlie the formation of chromosomal aberrations in adenocarcinomas and squamous cell carcinomas.

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Section: Introductionmentioning

confidence: 99%

Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas

et al. 2005

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“…All three tumor types showed multiple gains and losses, including gains at 20q13 and 8q, which have been recognized as recurrent in gastroesophageal tumors [9,11,12]. Gain of 20q13 has also been described in other tumor types and has been suggested to be of prognostic value in e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The genomic profiles of EA and JA showed extensive similarity, though gain of 12q was overrepresented in EA and gain of 18q in JA. A number of genetic regions have been reported to discriminate between EA and JA, but none of these have been validated and overall the similarities by far outnumber the differences, suggesting similar and to a large extent shared tumorigenic pathways [8][9][10]12].…”

Section: Discussionmentioning

confidence: 99%

“…EA as well as GA have demonstrated complex genetic alterations and gene expression changes [6,7]. Though multiple genetic similarities have been recognized between EA and JA, differences with losses of 5q, 8p, 14q and gains of 2q, 6p, 12p and 20q to be discriminative have also been suggested [8,9,[10][11][12]. With the aim to obtain a detailed genetic picture of gastroesophageal adenocarcinomas and to identify key genes and pathways herein, we applied a combined array-based gene expression and genomic profiling analysis to adenocarcinomas in the esophagus, the gastroesophageal junction, and the gastric body.…”

Section: Introductionmentioning

confidence: 99%

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Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array–comparative genomic hybridization

Isinger-Ekstrand

Johansson

Ohlsson

et al. 2010

Cancer Genetics and Cytogenetics

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“…The genetic and molecular changes underlying the development of Barrett's esophageal adenocarcinoma remain poorly understood. Genetic analysis of these cancers reveals frequent chromosomal losses (4q, 5q, 9p, and 18q), chromosomal gains (8q, 17q, and 20q), and occasional gene amplifications (7q, 8q, and 17q) [59]- [61]. Efforts to match specific chromosomal aberrations with particular genes have met with varying degrees of success.…”

Section: Genetic Factors For Esophageal Adenocarcinomamentioning

confidence: 99%

Esophageal Carcinogenesis

Watanabe¹,

Shimizu²,

Kochi³

et al. 2014

OJPathology

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Esophageal cancer is the sixth leading cause of cancer death and remains one of the least survivable cancers. Esophageal cancers show wide variations in incidence in different population, suggesting that environmental or lifestyle risk factors could be controlled to reduce risk of these diseases. There are two major histopathologic types (squamous cell carcinoma and adenocarcinoma) of esophageal epithelial malignancy. Recently, the rate of adenocarcinoma is increasing in developed countries: in the United States, 50% or more is adenocarcinoma and, in about 70%, the increase especially in a white male serves as adenocarcinoma. Esophageal adenocarcinoma develops in the lower esophagus. In contrast, in Japan, the increase in adenocarcinoma is not clear and most (90%) of esophageal cancers are squamous cell carcinoma. Such squamous cell carcinoma occurs onto the middle part esophagus mostly, and 60% or more of the whole esophagus cancer also develops in the middle and upper parts. These differences also influence the treatment results. The scope of this article is to discuss carcinogenesis in the esophagus by giving an overview about its histopathological characteristics and molecular mechanisms.

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DNA copy number profiling in esophageal Barrett adenocarcinoma:

Cited by 39 publications

References 26 publications

Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas

Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas

Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array–comparative genomic hybridization

Esophageal Carcinogenesis

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