DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma

Charli-Joseph, Yann; Saggini, Andrea; Doyle, Leona A.; Fletcher, Christopher D.�M.; Weier, Jingly F.; Mirza, Sonia; Vemula, Swapna; LeBoit, Philip E.

doi:10.1016/j.jaad.2014.03.015

Cited by 20 publications

(3 citation statements)

References 18 publications

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“…19 Deep fibrous histiocytoma is recognized by polymorphous spindle cells arranged in short fascicles and a storiform pattern, featuring peripheral collagen trapping and lacking STAT6 expression. 20 Mammary-type myofibroblastoma is characterized by short fascicles of spindled cells with thick collagen bands, often coexpressing CD34, desmin, and ER, but not STAT6. 21 A subset of solitary fibrous tumors may lack hemangiopericytoma-like vasculature, appearing densely cellular and monomorphic and mimicking dermatofibrosarcoma protuberans.…”

Section: Discussionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Cheek: Navigating Pathology and Advanced Multivariate Risk Stratification Assessment Models: A Clinicopathologic Challenge

Shaker,

Phelps,

Niedt

et al. 2024

The American Journal of Dermatopathology

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Section: Discussionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Cheek: Navigating Pathology and Advanced Multivariate Risk Stratification Assessment Models: A Clinicopathologic Challenge

Shaker,

Phelps,

Niedt

et al. 2024

The American Journal of Dermatopathology

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“…[ 7 ] Advanced techniques for distinguishing the tumors include fluorescent in situ hybridization (FISH) probe analysis for the t(17;22) translocation found in DFSP or array-based comparative genomic hybridization (CGH) assessment for DNA copy number changes. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Cellular dermatofibroma: A hyperkeratotic indurated plaque on the thigh

Elbendary

Griffin

Elston

et al. 2016

Indian Dermatol Online J

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“…It is considered a benign tumor but there exist some variants, such as the cellular one, that can present high local recurrence rates but low metastatic potential 2–5 . Only a few cases that progressed to metastasis have been reported in the medical literature 4,6–11 …”

Section: Introductionmentioning

confidence: 99%

Recurrent and metastatic cellular cutaneous fibrous histiocytoma: A case report and literature review

Fuentes‐Sánchez,

Pena‐Burgos,

Tapia‐Viñe

et al. 2023

J Cutan Pathol

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Cutaneous fibrous histiocytoma (FH) is considered a benign dermal tumor. The cellular variant is rare and poorly documented. Besides presenting a high risk of local recurrence, it has a low but serious metastatic potential. We present a case of metastatic cellular FH and also review the literature on this tumor, given its unusual metastatic development. A 47‐year‐old male patient presented with a lesion in the anterior surface of the right thigh, which has been present since adolescence but had grown during last year. Anatomopathological evaluation revealed a cellular FH, and the lesion was completely removed. Six months later, tumor recurrence with multiple compartment muscle involvement and pulmonary metastasis were detected. Both lesions were completely resected and after 3 years of follow‐up, the patient is asymptomatic and free of the disease. We conclude that FH should be carefully sampled to detect variants with high local recurrence rates or with some metastatic risk such as the cellular one. We recommend wide surgical resection and a close follow‐up including chest x‐rays or thorax computed tomography (CT) in all cellular FH cases with local recurrence.

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DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma

Cited by 20 publications

References 18 publications

Solitary Fibrous Tumor of the Cheek: Navigating Pathology and Advanced Multivariate Risk Stratification Assessment Models: A Clinicopathologic Challenge

Solitary Fibrous Tumor of the Cheek: Navigating Pathology and Advanced Multivariate Risk Stratification Assessment Models: A Clinicopathologic Challenge

Cellular dermatofibroma: A hyperkeratotic indurated plaque on the thigh

Recurrent and metastatic cellular cutaneous fibrous histiocytoma: A case report and literature review

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