DNA Content of Ovarian Immature Teratomas and Malignant Germ Cell Tumors

Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements

“…Baker et al 32 found that nine of 11 immature teratomas were diploid (with the two immature teratomas classified as aneuploid later being found to contain other GCT elements) and the majority of other GCT subtypes were aneuploid, with a mean DNA index of 1.85, the latter result similar to that found in adult testicular GCTs. Kraggerud et al 11 examined 25 ovarian GCTs, finding gains of 12p in 67% of dygerminomas and in 75% of yolk sac tumors; however, no gain of 12p was found in 11 immature teratomas.…”

“…2,17 Conversely, evidence supporting the origin of prepubertal testicular teratomas from benign germ cells includes a lack of chromosome 12p amplification, 29 a generally diploid, 46 XY karyotype, 30 normal findings on comparative genomic hybridization studies, 31 and lack of IGCNU. 18 It is also well established that most ovarian teratomas derive from i(12p) in ovarian teratomas C Poulos et al i(12p) in ovarian teratomas C Poulos et al benign germ cells in a parthenogenetic-like fashion based on their cytogenetics, 11,12 ploidy, 32 and molecular biologic findings. 10 In contrast to most testicular teratomas, they lack karyotypic abnormalities, including i(12p), but have a normal, 46, XX karyotype, 11,33 contain a diploid amount of DNA, 32 and show a homozygous pattern for polymorphic markers.…”

“…18 It is also well established that most ovarian teratomas derive from i(12p) in ovarian teratomas C Poulos et al i(12p) in ovarian teratomas C Poulos et al benign germ cells in a parthenogenetic-like fashion based on their cytogenetics, 11,12 ploidy, 32 and molecular biologic findings. 10 In contrast to most testicular teratomas, they lack karyotypic abnormalities, including i(12p), but have a normal, 46, XX karyotype, 11,33 contain a diploid amount of DNA, 32 and show a homozygous pattern for polymorphic markers. 9,10 The latter observation suggests a parthenogenetic-type origin from a germ cell between meiosis I and meiosis II.…”

Tératome immature de l'ovaire avec gliomatose péritonéale. À propos d'un cas et revue de la littérature

“…En effet, les térato-mes immatures de grades 1 et 2 étaient tous diploïdes alors que les tératomes de grade 3 étaient tous aneuploïdes. Cependant, ces résultats n'ont pas été confirmés par l'étude de Baker et al qui ont retrouvé une majorité de tératomes immatures diploïdes, quel que soit le grade histologique [6].…”

Evaluation de la prise en charge des teratomes immatures de l'ovaire. A propos de trois cas et revue de la littérature

“…En effet, les tératomes immatures de grade 1 et 2 étaient tous diploïdes alors que les tératomes de grades 3 étaient tous aneuploïdes. Cependant, ces résultats n'ont pas été confirmés par l'étude de Baker et al qui ont retrouvé une majorité de tératomes immatures diploïde, quelque soit le grade histologique [6].…”