DNA content in adenoid cystic carcinomas

Franzen, G; Nordgård, Ståle; Boysen, Morten; Larsen, Petter L.; Halvorsen, Tore; Clausen, O. P. F.

doi:10.1002/hed.2880170111

Cited by 39 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analyses of chromosomal ploidy have shown that most classic non-solid ACC show a low degree of aneuploidy, much less than other types of carcinomas, but, ACC with solid histology show increased aneuploidy [51,52]. Studies using CGH and aCGH show a correlation of the degree of genetic alterations (change in DNA copy number, chromosome number, genetic deletion) with the degree of solid growth pattern [39,41,42], consistent with the notion that ACCs with solid histology represent a later stage in tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma: Clinical and Molecular Features

Moskaluk

2013

Head and Neck Pathol

View full text Add to dashboard Cite

The clinical features and common molecular alterations of adenoid cystic carcinoma (ACC) are reviewed in this paper. ACC is an uncommon neoplasm that most frequently arises in salivary glands and related tissue in the head and neck region. ACC has distinct histologic features, with cribriform and tubular growth patterns of basaloid cells displaying a predominantly myoepithelial cellular phenotype. This neoplasm also has uncommon clinical features of rare regional lymph node metastasis and a prolonged but relentlessly progressive clinical course. Clinical outcome in ACC is correlated to histologic grade, which is correlated to the degree of aneuploidy and genetic alterations present in the tumor genomes. Recent studies have identified that the majority of ACC contain alterations of the MYB gene, usually resulting in a fusion gene product with the NFIB gene by a t(6;9) translocation event. The molecular consequences of this alteration are incompletely understood, as are secondary molecular alterations that contribute to the neoplastic phenotype of ACC.

show abstract

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma: Clinical and Molecular Features

Moskaluk

2013

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…11 -14 Franzén et al 11 reported 51 patients treated at the National Hospital (Oslo, Norway) and observed that prognosis was adversely influenced by grade 3 histology ( p = .0001), DNA aneuploidy, and an S phase of 6% or greater ( p = .0044). Luna et al 14 reported a series of 26 patients with submandibular gland adenoid cystic carcinomas treated at The University of Texas M. D. Anderson Cancer Center (Houston, TX) and found that aneuploid tumors were associated with a higher likelihood of solid cytoarchitecture, lymph node metastases, and advanced stage.…”

mentioning

confidence: 99%

Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck

et al. 2004

View full text Add to dashboard Cite

Background. The purpose of this study was to analyze the results of radiotherapy (RT) alone or combined with surgery for adenoid cystic carcinoma.Methods. Between September 1966 and November 2001, 101 previously untreated patients were treated with curative intent with RT alone or combined with surgery. Follow-up ranged from 0.4 to 30.6 years (median, 6.6 years). All living patients had follow-up for at least 1 year.Results. The 5-and 10-year rates of local control were as follows: RT alone, 56% and 43%; surgery and RT, 94% and 91%; and overall, 77% and 69%. Multivariate analysis of local control revealed that T stage ( p = .0101) and treatment group ( p = .0008) significantly influenced this endpoint. The 5-and 10-year rates of distant metastases-free survival were 80% and 73%. The 5-and 10-year absolute survival rates were as follows: RT alone, 57% and 42%; surgery and RT, 77% and 55%; and overall, 68% and 49%. Multivariate analysis of absolute survival revealed that T stage ( p = .0043) and clinical nerve invasion ( p = .0011) significantly influenced this endpoint. The 5-and 10-year causespecific survival rates were as follows: RT alone, 65% and 48%; surgery and RT, 81% and 71%; and overall, 74% and 61%. Multivariate analysis revealed that T stage ( p = .0008) and clinical nerve invasion ( p = .0005) significantly influenced causespecific survival.Conclusions. The optimal treatment for patients with adenoid cystic carcinoma is surgery and adjuvant RT. A significant proportion of patients with incompletely resectable disease are cured after RT alone. Improvements in locoregional control are offset, in part, by the relatively high incidence of distant metastases.

show abstract

“…Franzén et al, 8,11 in two studies on adenoid cystic carcinoma, showed an association between tumor grade and DNA ploidy, and a similar conclusion was achieved by Hicks et al 40 in a series of 48 mucoepidermoid carcinomas. In our study, all the low grade carcinomas had a DNA diploid pattern.…”

Section: Discussionmentioning

confidence: 54%

“…2 Several new biomarkers with putative clinical relevance in the assessment of tumor behavior have been investigated recently including DNA flow cytometry, which allows a fast and automated estimation of ploidy status and cell proliferation of the neoplasms. Previous reports have suggested that DNA flow cytometric parameters may have prognostic utility in some histologic types of salivary gland carcinomas, [3][4][5][6][7][8][9][10][11] but the findings are not concordant among studies. [12][13][14][15][16] This in part may be related to the fact that cytometric analysis has been performed nearly exclusively in a retrospective manner using paraffin embedded material.…”

mentioning

confidence: 92%

“…[12][13][14][15][16] This in part may be related to the fact that cytometric analysis has been performed nearly exclusively in a retrospective manner using paraffin embedded material. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] The advantage of using this methodologic approach in this kind of relatively rare tumor with an indolent clinical course is the availability of an adequate disease follow-up, allowing a prompt evaluation of the prognostic utility of the studied parameters. However, it is well known that DNA histograms obtained from paraffin embedded material show, in many instances, poor quality due to excessive cell debris and wide peaks, which can obscure or falsely reveal the presence of abnormal stemlines, and further impair the reliability of S-phase determination.…”

mentioning

confidence: 99%

See 1 more Smart Citation