DNA Content and S-Phase Fraction in Male Breast Carcinomas

Hatschek, Thomas; Wingren, Sten; Carstensen, John; Hultborn, Ragnar

doi:10.3109/02841869409121770

Cited by 19 publications

(8 citation statements)

References 16 publications

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“…Hatschek et al (1994), in their series of 85 patients, reported that 58% of their male breast tumours were aneuploid and 42% were diploid. These results are almost identical to ours.…”

Section: Discussionmentioning

confidence: 99%

“…Neither of those studies found ploidy to be an independent prognostic variable. Hatschek et al (1994) also investigated the S-phase fraction and did not find it to be an independent prognostic factor. This is in contrast to findings in female breast-cancer patients (Merkel et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Very little has been published on ploidy and S-phase fraction in tumours of the male breast to date (Gattuso et al, 1992;Hatschek et al, 1994) in contrast to the extensive literature on the subject in the female breast cancer. This report compares the histological typing, tumour grading and results of flow cytometry in male breast cancer to what has been observed in malignant breast tumours of females in Iceland.…”

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confidence: 97%

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Male breast cancer in Iceland

et al. 1996

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These occurred in slightly older patients than the infiltrating ductal carcinomas and were diploid tumours. In this study 57% of the tumours were found to be aneuploid, but nearly 70?? of the invasive ductal carcinomas NOS were aneuploid. In general, the aneuploid tumours were larger, of higher average histological grade and had a higher mean S-phase value. The overall mean S-phase fraction was 7.2v0 which is similar to that found in female breast tumours in Iceland. It is concluded that the male-to-female ratio of breast carcinoma in Iceland is similar to that found in other Western countries. The age-standardised incidence has increased considerably in the last 20 years, in contrast to the rates reported from most other countries. Papillary tumours are unusually common in Icelandic males.o 1996 Wiley-Liss, Inc.Carcinoma of the vestigial male breast is rare. The male-tofemale ratio of breast cancer varies geographically, being about 1% in the Western countries (Hecht and Winchester, 1994). The ratio is significantly higher in some parts of Africa, and in Blacks in the Western countries (Bhagwandeen, 1972;El-Gazayerli and Abdel-Aziz, 1963; Simon et al., 1992).In recent years, epidemiological reports on tumours of the male breast in Scandinavia (Adami et al., 1989; Ewertz et al., 1989) and in most European countries (La Vecchia et al., 1992) have been published. Iceland was not included in these studies because of the small population (a quarter of a million people). No reports on the epidemiology and histological variables of carcinoma of the male breast in Iceland have previously been published.The purpose of this work is to report on all male breast cancers diagnosed in the 40-year time period 1955-1994 in Iceland. Epidemiological data are presented with histopathological classification of the tumours, histological grading and the results of DNA-analysis by flow cytometry.Very little has been published on ploidy and S-phase fraction in tumours of the male breast to date (Gattuso et al., 1992; Hatschek et al., 1994) in contrast to the extensive literature on the subject in the female breast cancer. This report compares the histological typing, tumour grading and results of flow cytometry in male breast cancer to what has been observed in malignant breast tumours of females in Iceland. MATERIAL AND METHODSInformation concerning male patients diagnosed with breast carcinoma in Iceland during the 40-year period 1955-1994 was obtained from the Icelandic Cancer Registry. After histological and clinical revision, malignant breast tumours were diagnosed in a total of 31 patients. All histological slides, including at least one re-cut H. and E.-stained section, were reviewed by 2 of the authors (J.G.J. and B.A.A.).All carcinomas were classified into main histologic groups according to the World Health Organisation Classification (1981). All carcinomas of the infiltrating ductal type NOS were graded according to the Bloom and Richardson method with the Nottingham/Tenows modification (Elston, 1987). Patient's age at di...

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“…Hatschek et al (1994), in their series of 85 patients, reported that 58% of their male breast tumours were aneuploid and 42% were diploid. These results are almost identical to ours.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

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Male breast cancer in Iceland

et al. 1996

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“…As in women, there is evidence that tumor size and axillary nodal involvement are prognostic factors in male breast cancer [4][5][6][7]. Less is known about the prognostic significance of hormone receptor status and specific pathologic features such as histological and nuclear grade in this group of patients.…”

Section: Introductionmentioning

confidence: 94%

Male breast cancer: An 11 year review of 66 patients

McLachlan

Erlichman

Liu

et al. 1996

Breast Cancer Res Tr

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A review was conducted of 66 men with carcinoma of the breast seen at this institution between 1981 and 1992. The results of the study suggest that there are many similarities between breast cancer in men and women. The most common clinical presentation was a lump in the breast. The majority of tumors were T1 or T2, and infiltrating ductal carcinoma was the predominant histological type. Axillary nodal status and histological grade were predictive of survival. The pattern of recurrence and survival rates were similar to those seen in women. Some differences, however, were evident. Tumors were centrally located in the majority of patients and there was a high frequency of nipple involvement. The hormone receptor positivity rate was high and the median age at presentation was older. In comparison to a previous report of the same disease from this institution 10 years ago, fewer patients underwent radical surgical procedures and more patients received adjuvant systemic therapy. These approaches are justified since there are many biological similarities between breast cancer in men and women.

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“…Several reports on flow cytometric analysis of DNA ploidy in archival male breast tumors have been published. Hatchek et al (25) reported that, of 85 male breast tumors examined, 57.6% were aneuploid or had multiple stem lines. Eight of 22 male breast tumors examined by Wolman et el.…”

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confidence: 99%