DNA content and MHC class II antigen expression in malignant melanoma: clinical course.

Žaloudík, Jan; Moore, Michael G.; Ghosh, Anna K; Mechl, Zdeněk; Rejthar, A

doi:10.1136/jcp.41.10.1078

Cited by 65 publications

(27 citation statements)

References 36 publications

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“…Esteban et al [35] studied squamous cell carcinoma of the larynx and reported that HLA-DR antigen expression is associated with an excellent prognosis. On the other hand, Zaloudik et al [36] reported that HLA-DR antigen positivity is related to a poor prognosis in malignant melanoma. In cancers of the gastrointestinal tract, Sadanaga et al [3] studied esophageal squamous cell carcinoma and reported that the local immune response to the HLA-DR antigen may prevent tumor invasion.…”

Section: Discussionmentioning

confidence: 99%

Combined Expression of HLA-DR Antigen and Proliferating Cell Nuclear Antigen Correlate with Colorectal Cancer Prognosis

et al. 1998

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HLA-DR antigen expression and the proliferating cell nuclear antigen labeling index (PCNA-LI) were examined immmunohistochemically in 59 surgically resected advanced colorectal cancers to clarify the clinicopathologic significance of the HLA-DR antigen. HLA-DR antigen expression was detected in 33 (56%) of the 59 lesions, which showed less frequent liver metastasis than lesions without HLA-DR antigen expression (40 vs. 68%; p < 0.05). Five-year survival rates of patients with and without HLA-DR antigen expression were 50 and 19%, respectively. Lesions combining HLA-DR antigen expression and a relatively low PCNA-LI had the best prognosis. These results indicate that HLA-DR antigen expression, particularly combined with a low PCNA-LI, is an important outcome predictor in colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Combined Expression of HLA-DR Antigen and Proliferating Cell Nuclear Antigen Correlate with Colorectal Cancer Prognosis

et al. 1998

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“…As class II-expressing melanoma cells can present epitopes from melanoma-associated antigens (51,52,65,68), they can potentially stimulate anti-melanoma CD4 þ T cell responses. However, class II expression in melanoma correlates with advanced disease and poor survival (54,71). The mechanism of this apparent paradox is unclear.…”

Section: Role In Mhc Class Ii-restricted Antigen Presentationmentioning

confidence: 99%

Disulfide Reduction in the Endocytic Pathway: Immunological Functions of Gamma-Interferon-Inducible Lysosomal Thiol Reductase

Hastings

Cresswell

2011

Antioxidants & Redox Signaling

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Gamma-interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in most antigen presenting cells and is interferon g inducible in other cell types via signal transducer and activator of transcription 1. Normally, N-and C-terminal propeptides are cleaved in the early endosome, and the mature protein resides in late endosomes and lysosomes. Correspondingly, GILT has maximal reductase activity at an acidic pH. Monocyte differentiation via Toll-like receptor 4 triggers secretion of a disulfide-linked dimer of the enzymatically active precursor, which may contribute to inflammation. GILT facilitates major histocompatibility complex (MHC) class II-restricted processing through reduction of protein disulfide bonds in the endocytic pathway and is hypothesized to expose buried epitopes for MHC class II binding. GILT can also facilitate the transfer of disulfide-containing antigens into the cytosol, enhancing their cross-presentation by MHC class I. A variety of antigens are strongly influenced by GILT-mediated reduction, including hen egg lysozyme, melanocyte differentiation antigens, and viral envelope glycoproteins. In addition, GILT is conserved among lower eukaryotes and likely has additional functions. For example, GILT expression increases the stability of superoxide dismutase 2 and decreases reactive oxygen species, which correlates with decreased cellular proliferation. It is also a critical host factor for infection with Listeria monocytogenes. Antioxid. Redox Signal. 15, 657-668.

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“…MHC class II expression in melanoma has been previously associated with both shorter and longer survival (5)(6)(7). Indeed, MHC class II expression can make these tumors directly detectable by tumor-antigen-specific CD4 þ T cells that we and others previously have shown to be capable of generating Th1 responses in response to autologous tumor antigens (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 98%

Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity

et al. 2015

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DNA content and MHC class II antigen expression in malignant melanoma: clinical course.

Cited by 65 publications

References 36 publications

Combined Expression of HLA-DR Antigen and Proliferating Cell Nuclear Antigen Correlate with Colorectal Cancer Prognosis

Combined Expression of HLA-DR Antigen and Proliferating Cell Nuclear Antigen Correlate with Colorectal Cancer Prognosis

Disulfide Reduction in the Endocytic Pathway: Immunological Functions of Gamma-Interferon-Inducible Lysosomal Thiol Reductase

Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity

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