DNA cleavage mediated by water-soluble manganese corrole

Lu, Jun; Liu, Hai Yang; Shi, Lei; Wang, Xiangli; Xiao, Ying; Zhang, Lei; Ji, Liang; Zhang, Lin; Chang, C. K.

doi:10.1016/j.cclet.2010.09.005

Cited by 24 publications

(8 citation statements)

References 18 publications

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“…However, theoretical endeavors continue to make new structural assignments based on the IR-MPD spectra. 27 For neutral Si clusters, experimental data is spare and is mainly limited to ionization efficiency 12 or bracketing measurements. 11 The information on the ionization energy (IE) of a system can be used to rule out some isomers predicted by theory, but it is often not sufficient to decide for a single isomer.…”

Section: Introductionmentioning

confidence: 99%

Gas-phase structures of neutral silicon clusters

Haertelt

Lyon

Claes

et al. 2012

The Journal of Chemical Physics

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Vibrational spectra of neutral silicon clusters Si(n), in the size range of n = 6-10 and for n = 15, have been measured in the gas phase by two fundamentally different IR spectroscopic methods. Silicon clusters composed of 8, 9, and 15 atoms have been studied by IR multiple photon dissociation spectroscopy of a cluster-xenon complex, while clusters containing 6, 7, 9, and 10 atoms have been studied by a tunable IR-UV two-color ionization scheme. Comparison of both methods is possible for the Si(9) cluster. By using density functional theory, an identification of the experimentally observed neutral cluster structures is possible, and the effect of charge on the structure of neutrals and cations, which have been previously studied via IR multiple photon dissociation, can be investigated. Whereas the structures of small clusters are based on bipyramidal motifs, a trigonal prism as central unit is found in larger clusters. Bond weakening due to the loss of an electron leads to a major structural change between neutral and cationic Si(8).

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Section: Introductionmentioning

confidence: 99%

Gas-phase structures of neutral silicon clusters

Haertelt

Lyon

Claes

et al. 2012

The Journal of Chemical Physics

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“…It showed that manganese N-confused porphyrin 1 was stable enough in the process of DNA cleavage. Based on these investigations, we suggested the oxidative cleavage of DNA by manganese N-confused porphyrin 1 in the presence of H 2 O 2 is related to the central manganese ion and · OH species [10].…”

Section: Nuclease Activity Studiesmentioning

confidence: 97%

“…Serum albumin (SA) is the most abundant carrier protein whose in vivo binding to drugs could significantly affect the pharmaceutical process and toxicity of drugs [9]. The interactions of DNA or serum albumin (SA) with porphyrinoids, such as corroles [10][11][12][13][14], phthalocyanines [15] and porphyrins [16][17][18][19] have drawn much attention for their potential clinical uses.…”

Section: Introductionmentioning

confidence: 99%

“…It is well-known that the transition-metal complexes of porphyrinoids, such as manganese porphyrins and manganese corroles [10][11][12]19] as nuclease mimics, exhibit excellent catalytic activity for oxidative DNA cleavage. The transition-metal complexes of N-confused porphyrin have been demonstrated to be potent catalysts in cyclopropanation of styrene with high trans-selectivity [33,34] and oxygen atom transfer reactions [35].…”

Section: Introductionmentioning

confidence: 99%

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The magnetic properties, DNA/HSA binding and nuclease activity of manganese N-confused porphyrin

Peng

Ali

et al. 2016

J. Porphyrins Phthalocyanines

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The first oxidative cleavage of DNA by manganese N-confused porphyrin [chloro(2aza-2-methyl-5,10,15,20-tetrakis(p-chlorophenyl)-21-carbaporphyrin)manganese(III), 1] using H 2 O 2 as oxidant agent and its magnetic, calf thymus DNA(ct-DNA)-and human serum albumin (HSA) binding properties were investigated. The magnitude of the axial (D) zero-field splitting for the mononuclear Mn(III) center in 1 was determined to be approximately 2.71 cm -1 by paramagnetic susceptibility measurements. The DNA-and HSA binding experimental results showed that 1 bound to ct-DNA via an outside groove binding mode and the hydrophobic cavity located in subdomain IIA of HSA with the binding constant of 4.144 × 10 5 M -1 and ~10 6 M -1 , respectively. Thermodynamic parameters revealed that both DNA-and HSA binding were spontaneous process. The main driven forces were the hydrogen bond and van der Waals for the former, but hydrophobic interaction for the latter, which were further confirmed by molecular docking modeling. Manganese N-confused porphyrin 1 could cleave the supercoiled plasmid DNA efficiently in the presence of hydrogen peroxide. Hydroxyl radical ( · OH) was found the active species for oxidative damage of DNA.

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“…Metal corrole complexes have received considerable interest because of their close similarity with metal porphyrins (1,2). Successful preparation of water-soluble corroles has promoted the application of corrole derivatives in bioinorganic chemistry (3)(4)(5)(6)(7)(8)(9)(10). Because of the amphilicity and bipolarity of water-soluble sulfonated corroles, they may spontaneously form tightly bound conjugates with proteins, such as human serum albumin (HSA) and transferrin (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

DNA/HSA interaction and nuclease activity of an iron(III) amphiphilic sulfonated corrole

et al. 2015

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The DNA binding of amphiphilic iron(III) 2,17-bis(sulfonato)-5,10,15-tris(pentafluorophenyl)corrole complex (Fe-SC) was studied using spectroscopic methods and viscosity measurements. Its nuclease-like activity was examined by using pBR322 DNA as a target. The interaction of Fe-SC with human serum albumin (HSA) in vitro was also examined using multispectroscopic techniques. Experimental results revealed that Fe-SC binds to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10(4) M(-1). This iron corrole also displays good activity during oxidative DNA cleavage by hydrogen peroxide or tert-butyl hydroperoxide oxidants, and high-valent (oxo)iron(V,VI) corrole intermediates may play an important role in DNA cleavage. Fe-SC exhibits much stronger binding affinity to site II than site I of HSA, indicating a selective binding tendency to HSA site II. The HSA conformational change induced by Fe-SC was confirmed by UV/Vis and CD spectroscopy.

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DNA cleavage mediated by water-soluble manganese corrole

Cited by 24 publications

References 18 publications

Gas-phase structures of neutral silicon clusters

Gas-phase structures of neutral silicon clusters

The magnetic properties, DNA/HSA binding and nuclease activity of manganese N-confused porphyrin

DNA/HSA interaction and nuclease activity of an iron(III) amphiphilic sulfonated corrole

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