DNA cleavage activities and mechanism of a novel heterodinuclear macrocyclic complex

The reaction of Cu(NO3)2·3H2O with an N2O2 tetradentate amino alcohol, N,N‐dibenzyl‐N′,N′‐bis(2‐hydroxyethyl)ethylenediamine (H2L), afforded the mononuclear copper complex [Cu(H2L)(NO3)](NO3) (1), which has been used to construct a series of di‐, tri‐, and tetranuclear homo‐ and heterometallic complexes. Complex 1 dimerized in the presence of NEt3 to form the Cu2 complex [Cu2(HL)2](NO3)2 (2) by the deprotonation of one of the two hydroxy groups in the H2L ligand. The reaction of 1 with Cu(OCOH)2 in the presence of NEt3 afforded the Cu3 complex [Cu3(HL)2(OCOH)2](NO3)2 (5). The metalloligand {Cu(HL)}+ derived from 1 reacted with M(OAc)2 (M = Cu, Co, Zn, Ni) in the absence of NEt3 to form the asymmetric CuM dinuclear complexes [CuM(HL)(OAc)(NO3)2] [M = Cu (3a), Co (3b), Zn (3c), Ni (3d)], whereas in the presence of NEt3 a unit of M(OAc) was captured by two metalloligands to give the bent CuMCu trinuclear complexes [Cu2M(HL)2(OAc)2(NO3)](NO3) [M = Cu (4a), Co (4b), Mn (4c)], which were further transformed into the linear CuMCu trinuclear complexes [Cu3(HL)2{(PhO)2PO2}2](NO3)2 (7a) and [Cu2M(HL)2{(PhO)2PO2}2(MeOH)2](NO3)2 [M = Co (7b), Mn (7c)] with the aid of diphenyl phosphate bridging ligands. When (PhO)PO2(OH) was used as an auxiliary bridging ligand in the reaction of 1 with M(OAc)2 and NEt3, the Cu2M2 tetranuclear complexes [Cu2M2(HL)2{(PhO)PO3}2(NO3)2] [M = Co (8a), Zn (8b)] were synthesized. These results demonstrate that the mononuclear copper synthon with the N2O2 tetradentate amino alcohol ligand {Cu(H2L)}2+ generates the quite useful metalloligand {Cu(HL)}+ by the deprotonation of a hydroxy group, and subsequent reactions lead to the construction of a series of homo‐ and heterometal complexes containing Cu2, CuM (M = Cu, Co, Zn, Ni), bent‐CuMCu (M = Cu, Co, Mn), linear‐CuMCu (M = Cu, Co, Mn), and Cu2M2 (M = Co, Mn) cores in a systematic and selective manner.

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Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes

Kumar

Vashistha

Das

et al. 2022

J Incl Phenom Macrocycl Chem

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DNA cleavage activities and mechanism of a novel heterodinuclear macrocyclic complex

Cited by 13 publications

References 26 publications

Macrocyclic dinuclear nickel(II) and manganese(II) complexes: synthesis, X-ray crystal structures, DNA cleavage, and antimicrobial activity studies

Macrocyclic dinuclear nickel(II) and manganese(II) complexes: synthesis, X-ray crystal structures, DNA cleavage, and antimicrobial activity studies

Systematic Synthesis of Di‐, Tri‐, and Tetranuclear Homo‐ and Heterometal Complexes Using a Mononuclear Copper Synthon with a Tetradentate Amino Alcohol Ligand

Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes

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