DNA-cell-binding (DCB) assay for suspected carcinogens and mut agens

Kubinski, H.; Gutzke, Glen E.; Kubinski, Z.O.

doi:10.1016/0165-1218(81)90118-x

Cited by 159 publications

(15 citation statements)

References 26 publications

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“…Hypothetical route of oxidative polymerization of DAB in rat liver mitochondria [1] presence of an activating extract of rat liver [9]. Inadequate validation of this test and the unsatisfactory data presentation make it impossible to draw any conclusions from the study.…”

Section: Genotoxicitymentioning

confidence: 99%

3,3′‐Diaminobenzidine [MAK Value Documentation, 1992]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 3 (1992) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects on Animals Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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Section: Genotoxicitymentioning

confidence: 99%

3,3′‐Diaminobenzidine [MAK Value Documentation, 1992]

2012

The MAK‐Collection for Occupational Health and Safety

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“…In earlier studies, aniline was found t o be non mutagenic in Salmonella ryphirnuriurn . It is also reported to b e non-genotoxic in various assay systems with different genetic endpoints in Escherichia coli (9,(23)(24)(25)(26)(27)(28)(29). Negative results are also reported for tests in Bacillus subtilis (12,13,30), Aspergillus nidulans (31,32), Saccharomyces cerevisiae (23), and silkworms, (12,13,34).…”

Section: Introductionmentioning

confidence: 99%

Studies on the mutagenicity of aniline in association with norharman in the Salmonella/mammalian microscome assay

Shahin¹

1989

Intern J of Cosmetic Sci

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Synopsis The mutagenicity of aniline was investigated in association with norharman using Aroclor 1254-induced and uninduced liver S9 fractions. The non-mutagenicity of aniline in the Salmonella/mammalian microsome test was also re-examined under various experimental conditions. Aniline caused no increase in the number of revertants per plate in Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538 and TA98 at concentrations of up to 5000 mug/plate. S9 preparations from rat liver, hamster liver, rat spleen, or hamster spleen were all ineffective in activating aniline to a mutagen in tests using various concentrations of S9 in S9 mix. In contrast to the results with aniline alone, mixtures of aniline and norharman were mutagenic in strain TA1538 in the presence of S9 fractions from liver of rats pretreated with Aroclor 1254. The observed mutagenicity decreased as a function of the concentration of S9 in S9 mix. In the presence of uninduced liver S9 preparations, the mutagenicity of the mixture of the two compounds was slight (three-fold).

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“…In another in vitro test, in which the cyclohexane-induced binding of exogenous DNA to Escherichia coli cells was determined (Kubinski et al 1981), no effect of cyclohexane was seen.…”

Section: Genotoxicitymentioning

confidence: 99%

Cyclohexane [MAK Value Documentation, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 13 (1999) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Man Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Effects on skin and mucous membranes Reproductive and developmental toxicity Genotoxicity Carcinogenicity Manifesto (MAK value/classification) Estimation of the spermatotoxic effect in man Derivation of the MAK value

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DNA-cell-binding (DCB) assay for suspected carcinogens and mut agens

Cited by 159 publications

References 26 publications

3,3′‐Diaminobenzidine [MAK Value Documentation, 1992]

3,3′‐Diaminobenzidine [MAK Value Documentation, 1992]

Studies on the mutagenicity of aniline in association with norharman in the Salmonella/mammalian microscome assay

Cyclohexane [MAK Value Documentation, 1999]

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