DNA-bound metal ions: recent developments

Morris, Daniel L.

doi:10.1515/bmc-2014-0021

Cited by 41 publications

(31 citation statements)

References 77 publications

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“…Consequently, redox active metal ions are of particular interest for the chemistry of living systems. These ions cannot only bind to DNA, but they can also promote OD to DNA by mediating the production of oxygen reactive species (ROS) . In fact metal‐mediated OD to DNA has become an important topic in metal toxicity and carcinogenesis …”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that copper ions accumulation boosts ROS generation via Fenton‐like reactions . Accordingly, the search for antioxidants able not only of scavenging ROS but also of chelating metal ions has become an active area of research …”

Section: Introductionmentioning

confidence: 99%

“…The role of purines in this context is—to some extent—controversial. Albeit there seems to be no doubt that purines are excellent metal chelators, this feature alone may not be enough for them to act as protectors against metal‐induced OD. One of the earliest studies on the subject showed that purines are capable of protecting ascorbate from copper‐catalyzed oxidation, provided that the N atoms at positions 3 and 9 (Scheme ) are unsubstituted .…”

Section: Introductionmentioning

confidence: 99%

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Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

Castañeda‐Arriaga

Pérez-González

Álvarez-Idaboy

et al. 2017

Int J of Quantum Chemistry

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Oxidative damage to biomolecules is a serious health-threatening issue, which leads to the development of several diseases. Oxidative conditions are frequently catalyzed by metal ions. In this study, the role of purines in the copper-catalyzed oxidative stress was investigated using the density functional theory. The obtained results indicate that purines can have a dual behavior, acting as both protectors and promoters of oxidative stress. Their protection role arises from their known radical scavenging activity, as well as their ability to chelate Cu(II) leading to complexes that areto some extent-harder to reduce than free Cu(II). Conversely, their pro-oxidant role is a consequence of their reductant behavior, when deprotonated. Thus, the purines' anions can reduce Cu (II) to Cu(I), making the latter available to be involved in Fenton-like reactions. Consequently, mixtures of purines and Cu(II), at pHs where the fraction of deprotonated purines is rather significant, would yield • OH radicals. In turn, these very reactive radicals would damage biological targets such as lipids, proteins, and DNA.antioxidants, kinetics, pro-oxidants, rate constants, reaction mechanism 1 | I N TR ODU C TI ON Oxidative damage (OD) to biological targets such as lipids, proteins, and DNA is a serious health-threatening phenomenon. It has been held responsible, at least in part, for the onset and development of several diseases including cancer [1][2][3] ; rheumatoid arthritis [4][5][6] ; neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, depression, multiple sclerosis, and memory loss [7][8][9][10][11][12][13] ; cardiovascular diseases such as atherosclerosis, ischemia, hypertension, cardiac hypertrophy, heart failure, and cardiomyopathy [14][15][16][17] ; as well as renal [18][19][20] and pulmonary failure. [21][22][23] OD arises as a consequence of a chemical imbalance between the production and consumption of oxidants, known as oxidative stress (OS). [24] One of the most damaging oxidants in biological systems is the hydroxyl radical ( • OH). It can be produced, in the presence of metal ions such as Fe(II) or Cu(I), by Fenton or Fenton-like reactions (M q 1 H 2 O 2 ! M q11 1OH -1 • OH). However, the most stable and abundant forms of these two metals, under physiological conditions, are Fe(III) and Cu(II). Thus, • OH production would actually involve the metal-catalyzed Haber-Weiss recombination (HWR). It comprises two chemical steps. The first one is the reduction of the metal ions (M q11 1 O •2 2 ! M q 1 3 O 2 ) and the second one is the Fenton reaction. Consequently, redox active metal ions are of particular interest for the chemistry of living systems. These ions cannot only bind to DNA, but they can also promote OD to DNA by mediating the production of oxygen reactive species (ROS). [25] In fact metal-mediated OD to DNA has become an important topic in metal toxicity and carcinogenesis. [26][27][28][29]

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

Castañeda‐Arriaga

Pérez-González

Álvarez-Idaboy

et al. 2017

Int J of Quantum Chemistry

View full text Add to dashboard Cite

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“…The so-called “ion atmosphere” is known to dramatically affect the structural stability and functional dynamics of nucleic acids. Particularly, the non-specific binding of cations to the grooves of DNA double helix and the specific binding of some transition metals to defined domains of DNA are essential regulators of DNA-protein interactions and are linked to human disease and health 37 38 39 .…”

Section: Discussionmentioning

confidence: 99%

Effects of conformational ordering on protein/polyelectrolyte electrostatic complexation: ionic binding and chain stiffening

Cao

Fang

Nishinari

et al. 2016

Sci Rep

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Coupling of electrostatic complexation with conformational transition is rather general in protein/polyelectrolyte interaction and has important implications in many biological processes and practical applications. This work studied the electrostatic complexation between κ-carrageenan (κ-car) and type B gelatin, and analyzed the effects of the conformational ordering of κ-car induced upon cooling in the presence of potassium chloride (KCl) or tetramethylammonium iodide (Me4NI). Experimental results showed that the effects of conformational ordering on protein/polyelectrolyte electrostatic complexation can be decomposed into ionic binding and chain stiffening. At the initial stage of conformational ordering, electrostatic complexation can be either suppressed or enhanced due to the ionic bindings of K+ and I− ions, which significantly alter the charge density of κ-car or occupy the binding sites of gelatin. Beyond a certain stage of conformational ordering, i.e., helix content θ > 0.30, the effect of chain stiffening, accompanied with a rapid increase in helix length ζ, becomes dominant and tends to dissociate the electrostatic complexation. The effect of chain stiffening can be theoretically interpreted in terms of double helix association.

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“…Over recent years there has been an overwhelming interest in the interaction between deoxyribose nucleic acid (DNA) and small molecules. [1][2][3][4][5][6][7] DNA is an essential biological molecule that contains the molecular information needed for development, survival and reproduction of organisms. DNA plays a vital role in various biological processes such as gene expression, gene transcription, mutagenesis and synthesis of proteins through replication and transcription [8][9][10][11][12] , and consequently DNA has become the molecule of interest for many researchers.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the atenolol – DNA complex by viscometric, molecular docking and spectroscopic techniques

Kale

Ottoor

2018

Luminescence

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This paper discusses multi‐spectroscopic and molecular docking analysis of the interaction between atenolol (ATN) and deoxyribose nucleic acid (DNA) using alizarin (ALZ) as a spectroscopic probe. ATN is a β1‐receptor antagonist belonging to the β‐blocker class of molecules. Experimental findings that were based on different spectroscopic analysis, melting studies, viscometric analysis, 1H nuclear magnetic resonance and circular dichroism studies revealed the presence of a grove‐binding mode. The effect of ionic strength was also studied, and observations suggested that electrostatic interaction also played a minor role during interaction. Molecular docking analysis suggested that the dominant force for the grove‐binding phenomenon was hydrogen bonding between the 24‐H residue of ATN and O of the 10‐G residue, and the 40‐H residue of ATN and N of the 17‐A base residue. Competitive binding study of the ALZ−DNA complex with ATN showed that, despite an increase in the amount of ATN in the ALZ−DNA complex, the overall absorbance remained unchanged. The decrease in fluorescence in the ALZ−DNA system may be due to new non‐fluorescent ATN−DNA−ALZ complex formation.

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DNA-bound metal ions: recent developments

Cited by 41 publications

References 77 publications

Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

Role of purines on the copper‐catalyzed oxidative damage in biological systems: Protection versus promotion

Effects of conformational ordering on protein/polyelectrolyte electrostatic complexation: ionic binding and chain stiffening

Comprehensive analysis of the atenolol – DNA complex by viscometric, molecular docking and spectroscopic techniques

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