“…PSN-based methods provide is a solid framework to study protein structures (Angelova et al, 2011;Di Paola and Giuliani, 2015;Ghosh and Vishveshwara, 2008;Mariani et al, 2013;Verkhivker, 2019;Vuillon and Lesieur, 2015). We recently applied it to the study of other cancer-related proteins, allowing to shed light on the underlying structural communication among distal sites Lambrughi et al, 2016;Papaleo et al, 2012a;Sora and Papaleo, 2019) or to help in the classification of potential cancer passenger and driver missense mutations (Nygaard et al, 2016). In details, the PSN employs the graph formalism to identify a network of interacting residues in a given protein from the number of non-covalent contacts in the protein or other intramolecular interactions Viloria et al, 2017).…”