DNA binding properties and evaluation of cytotoxic activity of 9,10-bis-N-substituted (aminomethyl)anthracenes

Cytotoxic activity of acridin-3,6-diyl dithiourea hydrochlorides in human leukemia line HL-60 and resistant subline HL-60/ADR

“…The binding affinities were calculated from absorbance spectra according to the method of McGhee and vonHippel using data points from the Scatchard plot [18][19][20]. The binding data were fitted using a GNU Octave 2.1.73 software.…”

“…3). Fluorescence quenching To determine binding constants of studied compounds with DNA, UV-vis titration data from spectrophotometric analysis and McGhee and vonHippel plots [18][19][20] were used. Binding parameters for the interaction of AcrDTUs with calf thymus DNA are summarized in Table 2.…”

Synthesis, DNA Binding Properties and Bioactivity of Naphthalimide Poly(ethylene imine) Conjugates

“…对中 [12] . 通过非线性最小方差拟合曲线法 [13] 拟合最大 吸收变化的实验数据, 得到化合物 NI1～NI3 与 Ct-DNA 的键和常数, 分别为 [13,14] . 其原因可能是: 在 低浓度 Ct-DNA 时, 化合物 NI1 和 NI3 先嵌入到碱基对 中, 引起荧光的淬灭.…”

Disposable electrochemical DNA biosensor for environmental monitoring of toxicant 2-aminoanthracene in the presence of chlorine in real samples

“…DNA plays an important role in the life process, because it bears heritage information and instructs the biological synthesis of proteins and enzymes through the replication and transcription of genetic information in living cells. 1 After the discovery of electroactivity in nucleic acids at the beginning of the sixties, 2 many electrochemical approaches have been performed for the analysis of nucleic acids. 3 There is an increased interest in the application of DNA as biosensors as it is found to have interesting electrical conducting, electrochemical properties and unique hybridization behavior.…”