DNA binding of supramolecular mixed-metal complexes

Swavey, Shawn; Williams, Rodd Lee; Fang, Zhifeng; Milkevitch, Matthew; Brewer, Karen J.

doi:10.1117/12.446779

Cited by 3 publications

(3 citation statements)

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“…A series of Ru(II),Rh(III),Ru(II) trimetallic complexes, [{(bpy) 2 Ru(dpp)} 2 RhCl 2 ] 5+ , [{(bpy) 2 Os(dpp)} 2 RhCl 2 ] 5+ ,[{(tpy)RuCl(dpp)} 2 RhCl 2 ] 3+ , and [{(bpy) 2 Ru(bpm)} 2 RhCl 2 ] 5+ (dpp = 2,3-bis(2-pyridyl)pyrazine; Fig. 13), were studied to understand the impact of component variation on the biological activity [107–111]. The HOMO in each complex is localized on the Ru(II) or Os(II) center.…”

Section: Oxygen-independent Dna Modificationmentioning

confidence: 99%

Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

Knoll

Turró

2015

Coordination Chemistry Reviews

374

303

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The use of visible light to produce highly selective and potent drugs through photodynamic therapy (PDT) holds much potential in the treatment of cancer. PDT agents can be designed to follow an O2-dependent mechanism by producing highly reactive species such as 1O2 and/or an O2 independent mechanism through processes such as excited state electron transfer, covalent binding to DNA or photoinduced drug delivery. Ru(II)-polypyridyl and Rh2(II,II) complexes represent an important class of compounds that can be tailored to exhibit desired photophysical properties and photochemical reactivity by judicious selection of the ligand set. Complexes with relatively long-lived excited states and planar, intercalating ligands localize on the DNA strand and photocleave DNA through 1O2 production or guanine oxidation by the excited state of the chromophore. Photoinduced ligand substitution occurs through the population of triplet metal centered (3MC) excited states and facilitates covalent binding of the metal complex to DNA in a mode similar to cisplatin. Ligand photodissociation also provides a route to selective drug delivery. The ability to construct metal complexes with desired light absorbing and excited state properties by ligand variation enables the design of PDT agents that can potentially provide combination therapy from a single metal complex.

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Section: Oxygen-independent Dna Modificationmentioning

confidence: 99%

Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

Knoll

Turró

2015

Coordination Chemistry Reviews

374

303

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“…This dpp 0/- couple is ca. 0.60 V more positive in the bimetallic complexes compared to the monometallic synthons consistent with the significant stabilization of the dpp (π*) LUMO upon complexation to the Pt II center . The second reduction in the bimetallic complexes is dpp −/2- in nature, indicative of a bridging dpp.…”

Section: Resultsmentioning

confidence: 54%

Multifunctional DNA Interactions of Ru−Pt Mixed Metal Supramolecular Complexes with Substituted Terpyridine Ligands

Jain¹,

Wang²,

Mashack³

et al. 2009

Inorg. Chem.

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The coupling of a light absorbing unit to a bioactive site allows for the development of supramolecules with multifunctional interactions with DNA. A series of mixed metal supramolecular complexes that couple a DNA-binding cis-PtIICl2 center to a ruthenium chromophore via a polyazine bridging ligand have been prepared, and their DNA interactions have been studied, [(TL)RuCl(dpp)PtCl2](PF6) (TL = tpy (2,2′:6′,2′′-terpyridine), MePhtpy (4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine), or t Bu3tpy (4,4′,4′′-tri-tert-butyl-2,2′:6′,2′′-terpyridine and dpp = 2,3-bis(2-pyridyl)pyrazine). This series provides for unique tridentate coordinated Ru(II) systems to photocleave DNA with preassociation with the DNA target via coordination of the Pt(II) center. Electronic absorption spectroscopy of the complexes displays intense ligand-based π→π* transitions in the UV region and metal to ligand charge transfer (MLCT) transitions in the visible region. The Ru(dπ)→dpp(π*) MLCT transitions occur at 545 nm, red-shifted relative to the 520 nm maxima for the monometallic synthons, [(TL)RuCl(dpp)](PF6). The title RuPt complexes display reversible RuII/III oxidative couples at 1.10, 1.10, and 1.01 V vs Ag/AgCl for TL = tpy, MePhtpy, and t Bu3tpy, respectively. The TL0/- reduction occurred at −1.43, −1.44, and −1.59 V vs Ag/AgCl for TL = tpy, MePhtpy, and t Bu3tpy, respectively. These complexes display a dpp0/- couple (−0.50 −0.55, and −0.59 V) significantly shifted to positive potential relative to their monometallic synthons (−1.15, −1.16, and −1.22 V), consistent with the bridging coordination of the dpp ligand. Coupling of (TL)RuIICl(BL) subunit to a cis-PtIICl2 site provides for the application of photochemically inactive RuII(tpy)-based chromophores in DNA photocleavage applications. The [(TL)RuCl(dpp)PtCl2]+ complexes display covalent binding to DNA and photocleavage upon irradiation with visible light modulated by TL identity. The redox, spectroscopic, DNA-binding, and photocleavage properties of a series of supramolecular complexes are presented.

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“…It has been reported that 1,10-phenanthroline copper complexes have the ability of distinguishing and splitting DNA and could be used as chemical nucleases. 27,28 Moreover, there are evidences that such complexes have activity of anti-AIDS and might be exploited in diagnostic applications. 29,30 In order to obtain more insight into the design of new drugs, highly sensitive reactive probes and diagnostic reagents, development of new complex and detailed understanding of how such complexes bind to DNA will be potentially useful.…”

Section: Introductionmentioning

confidence: 99%

Nucleic Acid Biosensor for Detection of Human Immunodeficiency Virus Using Aquabis(1,10‐phenanthroline)copper(II) Perchlorate as Electrochemical Indicator

Niu¹,

Wang

2008

Chin. J. Chem.

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DNA binding of supramolecular mixed-metal complexes

Cited by 3 publications

References 0 publications

Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy

Multifunctional DNA Interactions of Ru−Pt Mixed Metal Supramolecular Complexes with Substituted Terpyridine Ligands

Nucleic Acid Biosensor for Detection of Human Immunodeficiency Virus Using Aquabis(1,10‐phenanthroline)copper(II) Perchlorate as Electrochemical Indicator

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