DNA binding of iron(II) complexes with 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline: salt effect, ligand substituent effect, base pair specificity and binding strength

Synthesis, structure and interactions with DNA of novel tetranuclear, [Mn4(II/II/II/IV)] mixed valence complexes

“…Furthermore, a distinct isosbestic point in the spectrum at 287 nm accompanies the hypochromism as the DNA concentration is increased, clearly suggesting binding of CT-DNA to the tetranuclear cluster. The binding strength of complex 1 with CT-DNA is mirrored in the intrinsic binding constant K b , which represents the binding constant per DNA base pair and can be obtained by monitoring the changes in the absorbance at 330 nm with increasing concentrations of DNA, according to the following equation [60][61][62][63]:…”

“…The 3.25+/ Mn and 3.50+/Mn oxidation states have the best resemblance of the S 1 state of the OEC while the 3.75+/Mn state is the best model for the S 2 state. Besides the development of such complexes as models for the OEC, an emerging area of interest is the study of the interaction of such metal complexes with DNA, in an effort to identify new agents that can recognize or cleave DNA [16][17][18][19][20][21][22][23][24]. For this purpose, the knowledge of the mode and the extent of binding of metal complexes to DNA are very important.…”

Hemoglobin-driven iron-directed assembly of gold nanoparticles

“…Examination of the Jobs plot suggests 3 : 1 ligand to metal binding, which is consistent with literature reports for structurally related complexes. 54 The UV-vis curves (Fig. 3B) and the visible change in colour of the solution (Fig.…”

DNA Binding of Iron(II)-Phenanthroline Complexes: Effect of Methyl Substitution on Thermodynamic Parameters

“…Apart from the determination of the binding constants, the thermodynamic parameters of their DNA binding, which are essential for a better understanding of the factors that drive the binding event, have not been studied in any detail. We have recently investigated the effect of phenyl substituents and phenazine moieties on the thermodynamic parameters of a series of iron(II) mixed-ligand complexes containing phen and dip (4,7-diphenyl-phen) or dppz (dipyrido[2,3-a:2 ,3 -c]phenazine) upon binding to DNA [21,22]. On the basis of polyelectrolyte theory, we have also dissected the equilibrium binding constant (K b ) and binding free energy change (∆G 0 ) into their electrostatic and non-electrostatic portions.…”