DNA-binding and Photocleavage Studies of Ethylenediamine Cobalt(III) and Ruthenium(II) Mixed Ligand Complexes

Nagababu, Penumaka; Shilpa, M.; Mustafa, Bakheit; Ramjee, P.; Satyanarayana, S.

doi:10.1515/irm.2008.6.4.301

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…The absorption spectra of various concentrations of Y2O3-DNA with respect to constant concentration of CT-DNA (10 µg/ ml) is depicted in the Figure 2a. A maximum absorption at 206 nm is witnessed in the samples owing to the electronic transitions from components of DNA molecules such as purine and pyrimidine [13]. With increasing concentration of Y2O3, the samples exhibited a significant red shift, offering that there exists a strong interaction between the Y2O3 nanoparticles with CT-DNA.…”

Section: Resultsmentioning

confidence: 98%

Probe into DNA interaction, cell toxicity and antifungal activities of phyto-synthesized yttrium oxide (Y2O3) nanoparticles

Meenambal

Hema

Tomar

et al. 2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Green synthesis is considered to be eco-friendly approach in comparison to chemical mediated synthesis and hence the study demonstrates facile Nyctanthes arbortristis mediated phyto-synthesis of biocompatible yttrium oxide (Y2O3) nanoparticles. X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) were employed to confirm the formation of cubic Y2O3 nanoparticles. Further, the interaction of Y2O3 with calf thymus-DNA were scrutinized by UV-visible, fluorescence spectroscopy and agarose gel electrophoresis techniques and the results suggested the stabilization of CT-DNA by the biosynthesized Y2O3. Also, the synthesized Y2O3 does not exhibit any toxicity in SK-MEL, human melanoma cell lines. Further, the studies on antifungal activities of Y2O3 nanoparticles revealed significant inhibitory effects on the growth of plant pathogen Exserohilum rostratum causing Exserohilum leaf blight in pearl millet. Hence, the findings deliver the foundation for furtherbiological research investigations of Y2O3 and its application in phytopathogen control.

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Section: Resultsmentioning

confidence: 98%

Probe into DNA interaction, cell toxicity and antifungal activities of phyto-synthesized yttrium oxide (Y2O3) nanoparticles

Meenambal

Hema

Tomar

et al. 2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Synthesis, Characterization Luminiscence Studies and Microbial Activity of Ethylenediamine Ruthenium (II) Complexes with Dipyridophenazine Ligands

et al. 2010

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Three symmetric ligands 7-methyl dipyrido-[3,2-a;2',3'-c]phenazine (dppz-CH(3)), 7-nitro dipyrido-[3,2-a;2',3'-c]phenazine (dppz-NO(2)) and benzo[i]dipyrido-[3,2-a;2',3'-c]phenazine (dppn) and their ruthenium(II) complexes [Ru(en)(2)(L)][ClO(4)](2) (en= ethylenediamine), L= dppz-CH(3), dppz-NO(2) and dppn have been synthesized and characterized by IR, (1)H, (13)C NMR and Mass spectra. The interactions of these complexes with calf thymus DNA have been investigated by spectrophotometric, spectrofluorimetric, circular dichroism, viscosity and thermal denaturation studies. As the planar extension of the intercalative ligand increases, the interaction of the complex with DNA increases, indicating that the size and shape of the intercalalative ligand has a marked effect on the strength of interaction. The plot of log K versus log [Na(+)] yield a slope of -1.26, -1.53, -1.60 for the complexes 1, 2 and 3 respectively. These three complexes have been found to promote the cleavage of plasmid pBR 322 DNA upon irradiation.

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Ruthenium(II) ethylenediamine complexes with dipyridophenazine ligands: synthesis, characterization, DNA interactions, and antiproliferative activities

Shilpa

Devi

Nagababu

et al. 2013

Journal of Coordination Chemistry

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DNA-binding and Photocleavage Studies of Ethylenediamine Cobalt(III) and Ruthenium(II) Mixed Ligand Complexes

Cited by 4 publications

References 24 publications

Probe into DNA interaction, cell toxicity and antifungal activities of phyto-synthesized yttrium oxide (Y2O3) nanoparticles

Probe into DNA interaction, cell toxicity and antifungal activities of phyto-synthesized yttrium oxide (Y2O3) nanoparticles

Synthesis, Characterization Luminiscence Studies and Microbial Activity of Ethylenediamine Ruthenium (II) Complexes with Dipyridophenazine Ligands

Ruthenium(II) ethylenediamine complexes with dipyridophenazine ligands: synthesis, characterization, DNA interactions, and antiproliferative activities

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