DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mrow><mml:msup><mml:mrow><mml:mrow><mml:mtext>[</mml:mtext><mml:mrow><mml:mtext>Co</mml:mtext><mml:msub><mml:mrow><mml:mrow><mml:mtext>(</mml:mtext><mml:mrow><mml:mtext>en</mml:mtext></mml:mrow><mml:mtext>)</mml:mtext></mml:mrow></mml:mrow><mml:mtext>2</mml:mtext></mml:msub><mml:msub><mml:mrow><mml:mrow><mml:mtext>(</mml:mtext><mml:mrow><mml:mtext>py

Nagababu, Penumaka; Kumar, Dinesh; Reddy, Kotha Laxma; Kumar, K. Ashwini; Mustafa, Bakheit; Shilpa, M.; Satyanarayana, S.

doi:10.1155/2008/275084

Cited by 23 publications

(13 citation statements)

References 37 publications

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“…[Co(en) 2 (pyz) 2 ]Br 3 was synthesized as described earlier [22,23,24]. A mixture of cis-[Co(en) 2 Cl 2 ]Cl (1.43 g) and pyrazole (1 g) was dissolved in ethanol (6 ml).…”

Section: Synthesis Of [Co(en) 2 (Pyz) 2 ]Brmentioning

confidence: 99%

DNA-Binding and cytotoxicity of the cobalt(III) ethylenediamine pyrazole complex [Co(en)2(pyz)2]3+

Nagababu

Latha

Rajesh

et al. 2009

JICS

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The complex of cobalt(III) ethylenediamine was synthesized, isolated and characterized by UV-Vis, IR, and 1 H NMR spectral methods. The binding of the complex with calf thymus DNA was investigated by absorption and emission spectroscopy, viscosity measurements, DNA melting and DNA photocleavage. The spectroscopic studies together with the viscosity measurements and DNA melting studies indicated that the complex binds to calf thymus DNA in a nonintercalative mode. This complex is found to promote photocleavage of the DNA plasmid pBR322 and shows a cytotoxic effect against CHO cells.

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“…[Co(en) 2 (pyz) 2 ]Br 3 was synthesized as described earlier [22,23,24]. A mixture of cis-[Co(en) 2 Cl 2 ]Cl (1.43 g) and pyrazole (1 g) was dissolved in ethanol (6 ml).…”

Section: Synthesis Of [Co(en) 2 (Pyz) 2 ]Brmentioning

confidence: 99%

DNA-Binding and cytotoxicity of the cobalt(III) ethylenediamine pyrazole complex [Co(en)2(pyz)2]3+

Nagababu

Latha

Rajesh

et al. 2009

JICS

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“…Many ligands derived from pyridine containing precursors are capable to couple with metals, the resulted complexes exhibit anti-tumor activities. 17 Among metals, Cu (II) and Co(III) complexes with pyridine derivatives efficiently interact with DNA 18 and can bind the two strands of DNA in an effective manner. Pyridine containing compounds and its metal complexes get much attention in the field of catalysis i.e.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis, characterization and DFT calculations of 2-acetyl pyridine derivatives

Rashid¹,

Shahzad²,

Gul³

et al. 2017

Quim. Nova

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Deprotonation of 2-acetylpyridine was carried out in the presence of NaH as a phase transfer catalyst instead of NaOH to minimize side products formation. The products were then treated with two equivalents of alkyl/aryl halide to synthesize a variety of acetyl pyridine derivatives. The compounds were structurally characterized by 1 H-and 13 C-NMR spectroscopy in solution state. Structure of compound 2 was also confirmed in solid state by X-ray diffraction. Electronic properties such as Mulliken charges, frontier molecular orbitals (HOMO-LUMO), ionization energy (IE), electron affinity (EA), global hardness (η), Chemical Potential (μ) and Global electrophilicity (ω) of some compounds were investigated by the same theory using B3LYP-6-311G basis set.

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“…(HBT = 11H,13H-4,5,9,10,12,14-hexaaza-benzo-[b]-triphenylene). Recently, our group has reported [21][22][23][24][25] binding and photocleavage studies of several mixed ligand complexes of ruthenium(II) and cobalt(III). We chose to concentrate our work on ruthenium(II) complexes of polypyridyls, which have interesting DNA-binding properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, DNA interaction and photocleavage studies of ruthenium(II) complexes with 2-(pyrrole) imidazo[4,5-f]-1,10-phenanthroline as an intercalative ligand

Kumar

Reddy

Satyanarayana

2010

Transition Met Chem

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Three Ru(II) complexes, namely [Ru(bipy) 2-PRIP] 2? (1), [Ru(dmb) 2 PRIP] 2? (2), and [Ru(phen) 2 PRIP] 2?(3) (dmb = 4,4 0 -dimethyl-2,2 0 -bipyridine; PRIP = 2-(pyrrole) imidazo [4,5-f]-1,10-phenanthroline) have been synthesized and characterized by elemental analysis, mass spectra, IR, 1 H NMR and 13 C NMR. The DNA-binding properties of the three complexes with calf-thymus DNA (CT-DNA) were investigated by spectrophotometry, fluorescence methods and viscosity measurements. The results suggest that all three complexes bind to CT-DNA through intercalation. Also, when irradiated at 365 nm, the three complexes promote the photocleavage of plasmid pBR-322 DNA. Under comparable experimental conditions, complex 3 cleaves DNA more effectively than complexes 1 and 2.

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DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Co(en)2(py

Cited by 23 publications

References 37 publications

DNA-Binding and cytotoxicity of the cobalt(III) ethylenediamine pyrazole complex [Co(en)2(pyz)2]3+

DNA-Binding and cytotoxicity of the cobalt(III) ethylenediamine pyrazole complex [Co(en)2(pyz)2]3+

Facile synthesis, characterization and DFT calculations of 2-acetyl pyridine derivatives

Synthesis, DNA interaction and photocleavage studies of ruthenium(II) complexes with 2-(pyrrole) imidazo[4,5-f]-1,10-phenanthroline as an intercalative ligand

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