DNA binding and antitumor activities of zinc(II) complexes with some S-alkenyl derivatives of thiosalicylic acid

Effects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cells

“…The 1 H and 13 C NMR spectra of diamagnetic Zn(II) complex recorded in d 6-dimethylsulfoxide (DMSO-d 6 ) solution using tetramethylsilane (Me 4 Si) as internal standard . The chemical shift observed for the OH proton in the ligand (10.58 ppm) was not observed in the Zn(II) complex.…”

“…5-FU is related to severe adverse effects in the clinical application [12]; therefore, it is important to nd new anticancer agents that have no severe side effects on normal cells. Zinc is the second most plentiful trace element in the human body and an important micro-element that is essential for human physiology [13]. Moreover, zinc has a neuromodulator function in the brain as well as its other cellular functions [14].…”

Anti‐proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine

“…[18] Zinc coordination compounds have been very interesting due to their anticonvulsant, antidiabetic, antioxidant, and anti-proliferative/anti-tumor biological effects. [19][20][21][22] The beneficial therapeutic effects of Zn compounds are generally associated with lower toxicity and lower side effects compared to other metal-based drugs [23] because zinc does not cause a significant toxic effect in high doses compared to metals such as Fe, Cu, and Hg. [24][25][26] Therefore, zinc compounds continue to be investigated as potential new metal-based anticancer drugs as an alternative to other metal(II) complexes and platinum compounds.…”

Carbazole appendedtrans-dicationic pyridinium porphyrin finds supremacy in DNA binding/photocleavage over a non-carbazolyl analogue

“…[18][19][20][21][22] Paper Dalton Transactions cells. 35 In addition, various studies show that the tumor suppressor effects include altered metabolic effects, inhibition of proliferation, and inhibition of invasion by Zn. 36,37 The nitrogen-containing tricyclic aromatic compound carbazole was first isolated from coal tar in 1872 by Graebe and Glaser.…”

“…29–34 Similarly, when zinc coordinates with bioactive ligands, it is assumed to show less toxicity toward normal cells as compared to cancer cells. 35 In addition, various studies show that the tumor suppressor effects include altered metabolic effects, inhibition of proliferation, and inhibition of invasion by Zn. 36,37…”