DNA-binding and anti-oxidation properties of binuclear lanthanide(III) complexes of 8-hydroxyquinoline-7-carbaldehyde-(isonicotinyl)hydrazone

Zhang, Kejun; Lei, Ruixia; Liu, Jianning; Zhou, Tianlin; Zhou, Yang

doi:10.1080/00958972.2012.683485

Cited by 20 publications

(3 citation statements)

References 49 publications

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“…The significant quenching and red shift of the ICA-Cu fluorescence suggested that there was an interaction between the ICA-Cu and the DNA base pairs. The quenching efficiency could be calculated according to the linear Stern-Volmer equation [ 33 ], F 0 /F = 1 + K SV [Q]; here F 0 and F indicate the fluorescence intensity in the absence or presence of a compound at [Q], respectively. K SV indicates the Stern-Volmer dynamic quenching constant.…”

Section: Resultsmentioning

confidence: 99%

In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes

et al. 2017

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Indole-2-carboxylic acid copper complex (ICA-Cu) was successfully prepared and characterized through elemental analysis, IR, UV-Vis, 1H-NMR, TG analysis, and molar conductance, and its molecular formula was [Cu2(C9H6O2N)4(H2O)2]·2H2O. The binding ability of ICA-Cu to calf thymus DNA (CT-DNA) was examined by fluorescence spectrometry and the viscosity method. The results indicated that, upon the addition of increasing amounts of CT-DNA, the excitation and emission intensity of ICA-Cu decreased obviously and the excitation spectra shifted towards a long wavelength. ICA-Cu could displace ethidium bromide (EB) from the EB-DNA system, making the fluorescence intensity of the EB-DNA system decrease sharply; the quenching constant KSV value was 3.99 × 104 M−1. The emission intensity of the ICA-Cu-DNA system was nearly constant, along with the addition of Na+ in a series of concentrations. The fluorescence of the complex could be protected after the complex interacted with DNA. A viscosity measurement further supported the result that the ICA-Cu complex may interact with DNA in an intercalative binding mode. The antioxidant activities of ICA-Cu were evaluated by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, a hydroxyl radical (OH) scavenging assay, and a 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay. The ICA-Cu exhibited the highest inhibitory effects on the ABTS radical (94% inhibition at 60 µM), followed by OH and DPPH radicals (the degrees of inhibition being 71% and 56%, respectively). The in vitro cytotoxicity activity of ICA-Cu against two human breast cancer cell lines, MDA-MB-231 and MCF-7, was investigated by 3-[4,5-dimethyltiazol2-yl]-2.5-diphenyl-tetrazolium bromide (MTT) assay and cellular morphological analysis. The results showed that, upon increasing the concentration of ICA-Cu, an increase was observed in growth-inhibitory activity and the inhibition percentage were greater than 90% at 20 µM in both cell lines. Also, cellular morphological changes in the two cell lines agreed with the cytotoxicity results.

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Section: Resultsmentioning

confidence: 99%

In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes

et al. 2017

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“…This may be attributed to the presence of a phenyl ring in the ligand that facilitates. Therefore, the complexes may be regarded as efficient intercalators of DNA [51][52][53] . and Eu 3+ complex exhibits characteristic luminescence of trivalent metal ions, which indicates that the ligand is a good organic chelator to absorb and transfer energy to metal ions.…”

Section: Mass Spectral Studiesmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION, LUMINESCENCE AND DNA BINDING PROPERTIES OF Ln (III)-SCHIFF BASE FAMILY

Babu

Rao

Lee

2017

J. Chil. Chem. Soc.

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Pentadentate Schiff base ligand(N,N-bis(2-hydroxy-1-naphthylidene) diethylenetriamine) (H 2 L) that exhibits a N 3 O 2 donor set. Five rare earth complexes lanthanide (III), praseodymium (III), neodymium(III), samarium(III)and europium (III) complexes are synthesized and characterized based on elemental analyses, molar conductance, infrared, ultraviolet, thermo gravimetric, X-ray powder diffraction and mass spectral studies. Molar conductivity data suggests that the complexes are 1:1 electrolytics. Infrared spectral data suggest that the ligand binds through two naptholic oxygen atoms, two azomethine nitrogen atoms and one primary amine. IR studies reveal that the complexes contain both coordinating and ionic nitrate ligands. Thermal decomposition studies indicate the presence of two nitrate ions and two water molecules in the inner coordination sphere. Eu 3+ and Sm 3+ complexes exhibit luminescence properties. Further, the binding properties of these complexes with calf-thymus DNA have been investigated using absorption spectrophotometry.

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“…Various approaches can be visualized to synthesize or modify metal complex structures by utilizing the reactivity of this heterocycle with various derivatives [1][2][3][4][5][6][7][8][9][10][11][12]. 8HQ and its derivatives are also showing the bioactivities, including anticancer [13,14], antibacterial [15,16], antidyslipidemic and antioxidative properties [17], vasorelaxing properties [18], antivirus [19,20], and antiplatelet [21] activities.…”

Section: Introductionmentioning

confidence: 99%

Studies on metal complexes of 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one

Patel

2015

Res Chem Intermed

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Novel ligand 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one was synthesized by condensation of 5-(chloromethyl)-1,8a-dihydroquinolin-8-ol with 3-(thiazol-2-ylimino)indolin-2-one. Metal complexes of this ligand were prepared using various transition metal ion salts, viz., Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II). All synthesized compounds were characterized by various spectroscopic techniques. Thermogravimetric analysis of metal complexes was also carried out. Geometry of the metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. The ligand and metal complexes were screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa. The metal complexes are found more potent bactericides than the ligand. The interaction of ligand and its complexes with plasmid (pUC 19) DNA and calf thymus DNA was investigated by gel electrophoresis measurements. The superoxide dismutase mimetic activity of the ligand and its metal complexes has also been assessed for their ability to inhibit the reduction of nitrobluetetrazolium chloride.

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DNA-binding and anti-oxidation properties of binuclear lanthanide(III) complexes of 8-hydroxyquinoline-7-carbaldehyde-(isonicotinyl)hydrazone

Cited by 20 publications

References 49 publications

In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes

In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes

SYNTHESIS, CHARACTERIZATION, LUMINESCENCE AND DNA BINDING PROPERTIES OF Ln (III)-SCHIFF BASE FAMILY

Studies on metal complexes of 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one

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