DNA binding affinities, anti-oxidant, antimicrobial and molecular docking activities of Pd (II) complexes of chromone Schiff bases

Synthesis and characterization of the novel heteroannulated chromeno[2,3‐d]pyrimidines and chromeno[2,3‐d][1,3]thiazolo[3,2‐a] pyrimidines

“…Yield (0.62 g, 67%), mp >300 C. IR (KBr, cm À1 ): 3423 (OH), 3296 (NH), 1677 (C=O pyrimidine ), 1650 (C=O γ-pyrone ), 1610 (C=N), 1576 (C=C). (20), 136 (14), 120 (100), 92 (39), 77 (11), 64 (8) A mixture of compound 8 (0.84 g, 2 mmol) and chloroacetonitrile (0.3 g, 0.25 ml, 2 mmol), in DMF (10 ml) containing triethylamine (0.1 ml), was heated under reflux for 4 h. The yellow crystals deposited during heating were filtered, air dried and crystallized from AcOH/H 2 O, yield (0.51 g, 56%), mp > 300 C. IR (KBr, cm À1 ): 3430 (OH), 3343, 3253 (NH 2 ), 1680 (C=O pyrimidine ), 1649 (C=O γ-pyrone ), 1609 (C=N), 1580 (C=C). 1 (15), 136 (11), 120 (28), 92 (9),77 (16), 64 (7) A mixture of compound 8 (0.84 g, 2 mmol) and bromomalononitrile (0.29 g, 2 mmol), in DMF (10 ml) containing triethylamine (0.1 ml), was heated under reflux for 4 h. The dark-yellow crystals formed during heating were filtered, air dried and crystallized from DMF, yield (0.57 g, 59%), mp >300 C. IR (KBr, cm À1 ): 3423 (OH), 3332, 3256 (NH 2 ), 2225 (C ≡ N), 1682 (C=O pyrimidine ), 1656 (C=O γ-pyrone ), 1605 (C=N), 1572 (C=C).…”

“…1 (15), 136 (11), 120 (28), 92 (9),77 (16), 64 (7) A mixture of compound 8 (0.84 g, 2 mmol) and bromomalononitrile (0.29 g, 2 mmol), in DMF (10 ml) containing triethylamine (0.1 ml), was heated under reflux for 4 h. The dark-yellow crystals formed during heating were filtered, air dried and crystallized from DMF, yield (0.57 g, 59%), mp >300 C. IR (KBr, cm À1 ): 3423 (OH), 3332, 3256 (NH 2 ), 2225 (C ≡ N), 1682 (C=O pyrimidine ), 1656 (C=O γ-pyrone ), 1605 (C=N), 1572 (C=C). (23), 196 (10), 164 (8), 120 (13), 93 (11), 77 (14), 64 (8)…”

“…Chromone derivatives are considered as the most common natural occurring oxygen heterocyclic compounds [1,2]. Anti-Coronavirus [3], anti-HIV [4], anti-Tobacco Mosaic Virus [5], antidiabetic [6], anti-inflammatory [7], antioxidant [8], antitumor [9], anticancer [10,11], antiproliferative [12,13], antimicrobial [14], neuroprotective [15], and anti-Alzheimer's disease [16] are some of the biological activities of chromones. Substituted chromones are widely applied as corrosion inhibitors for steel in hydrochloric acid [17].…”

Advances in chromone-based copper(ii) Schiff base complexes: synthesis, characterization, and versatile applications in pharmacology and biomimetic catalysis

“…43 Chromone Schiff base ( II ) complexes with Pd 2+ have also been successfully prepared, characterized, and investigated for circulating tumor DNA (ctDNA) binding, radical scavenging, and antimicrobial potency. 44 In a recent study, a fluorescent molecule appended with rhodamine and chromone ( III ) was synthesized as an efficient sensor for Fe 3+ , Al 3+ , and Cr 3+ at trace levels. Further, they were assessed for anticancer activity and were found to be effective against MCF-7 cells, glucocorticoid, and progesterone receptors.…”

NiIIand CoIIbinary and ternary complexes of 3-formylchromone: spectroscopic characterization, antimicrobial activities, docking and modeling studies

“…Chromones are important natural compounds with a γ-pyrone heterocyclic ring structure. They are known for inhibiting enzymes, including mushroom tyrosinase and protein kinase-C. 1 Plant leaves and flowers are sources and contain chromone as a pigment. They are essential for the production of various xanthones, transition metal chelates, and heterocyclic compounds with oxygen.…”