“…DNA-based sensors and detection systems have in recent years been increasingly used in relation to detection of multiple DNA-modifying enzymes such as topoisomerases, nucleases and DNA repair enzymes [1,2,3,4,5,6,7,8,9]. In many cases, specially designed DNA oligonucleotides have been used to detect the enzymatic reaction by allowing for specific amplification of the DNA oligonucleotides, only after the correct enzymatic reaction has been performed [5,6,7,8,9,10].…”