DNA-Based Magnetic Nanoparticle Assembly Acts as a Magnetic Relaxation Nanoswitch Allowing Screening of DNA-Cleaving Agents

Perez, J. Manuel; O'loughin, Terence; Simeone, F. A.; Weissleder, Ralph; Josephson, Lee

doi:10.1021/ja017773n

Cited by 352 publications

(213 citation statements)

References 12 publications

(13 reference statements)

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“…The latter technology is based on supramolecular assemblies of nanoparticles that change from single to oligomeric fluid phase states, accompanied by five-to tenfold changes in R2 that are easily detectable by MRI. This approach has been used to sense (and image) DNA hybridization [79], DNA methylation and cleavage [80], and protein and protease activities [81]. More recently, hybrid magnetic nanoparticle-fluorescent probes have also been developed for combined anatomic and molecular imaging in living organisms [82,83].…”

Section: E Outlookmentioning

confidence: 99%

Shedding light onto live molecular targets

Weissleder

Ntziachristos

2003

Nat Med

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1,773

1,319

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Abstract-Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

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Section: E Outlookmentioning

confidence: 99%

Shedding light onto live molecular targets

Weissleder

Ntziachristos

2003

Nat Med

Self Cite

1,773

1,319

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“…105 Complementary to MRS assays dependent on the selfassembly of SPIO, assays relying the dispersion of SPIO have also been devised to detect endonuclease, and subsequently, methylase and protease activity. 105,106 Briefly, for endonuclease activity, two sets of SPIO were designed such that attached oligonucleotide sequences hybridized to form a restriction endonuclease recognition site. The T2 relaxation time decreased significantly when the two populations were combined.…”

Section: Protein and Enzyme Detectionmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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“…More specifically, superparamagnetic iron oxide particles in nano regime are extensively used in bioseperation for their well-established biocompatibility [19]. In addition, due to superparamagnetism of inorganic cores, recovery and further usage of these solids can be facilely achieved by applying external magnetic field [20].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Vinylphenyl Boronic Acid Microparticles for Surface Catalytic Performance in Esterification of Propionic Acid with Methanol

Kara¹,

Erdem²

2016

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY a - Applied Sciences and Engineering

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Magnetic vinylphenyl boronic acid microparticles, poly(ethylene glycol dimethacrylate-vinylphenyl boronic acid) [mpoly(EGDMA-VPBA)], produced by suspension polymerization, was found to be efficient solid acid catalyst for the esterification of methanol and propionic acid. Characterization techniques such as FT-IR, Elemental analyses, ICP-AES, ESR, SEM and N2 sorption showed that both of Fe3O4 and H2SO4 are bonded to the polymer successfully. Esterification was studied for different molar percentages of H2SO4 at temperature range of 50-70 o C. The apparent activation energy was found to be 28.4 kj.mol -1 for 10% H2SO4 doped m-poly(EGDMA-VPBA). Combining of strong acid H2SO4 with m-poly(EGDMA-VPBA), leads to materials with different functional properties. In addition, H2SO4 species could be introduced into the structure as acid centers, therefore this micro-dimensional catalyst has potential candidate for applications in the catalytic esterifications such as propionic acid with methanol.

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DNA-Based Magnetic Nanoparticle Assembly Acts as a Magnetic Relaxation Nanoswitch Allowing Screening of DNA-Cleaving Agents

Cited by 352 publications

References 12 publications

Shedding light onto live molecular targets

Shedding light onto live molecular targets

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Magnetic Vinylphenyl Boronic Acid Microparticles for Surface Catalytic Performance in Esterification of Propionic Acid with Methanol

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