DNA/Au-Pt bimetallic nanoparticles/graphene oxide-chitosan composites modified pencil graphite electrode used as an electrochemical biosensor for sub-picomolar detection of anti-HIV drug zidovudine
“…The study of Akbari Hasanjani and Zarei was also interesting. A modified pencil graphite electrode was made using deoxyribonucleic acid/Au-Pt bimetallic nanoparticles/graphene oxide–chitosan (DNA/Au-Pt BNPs/GO-CS/PGE) for the determination of zidovudine (ZDV), a type of drug broadly employed for the treatment of AIDS ( Figure 9 ) ( Akbari Hasanjani and Zarei, 2021 ). The modified electrode demonstrated a good electrocatalytic activity to the ZDV because of the effect of DNA and the synergetic effects of Au-Pt BNPs and GO-CS.…”
Section: Biosensormentioning
confidence: 99%
“…Furthermore, the modified electrode was successfully utilized to determine ZDV in human serum samples. Figure 9 A schematic of the construction of the DNA/Au-Pt BNPs/GO-CS/PGE electrochemical biosensor for ZDV detection Reprinted with permission from Akbari Hasanjani and Zarei (2021) Copyright 2021 Elsevier B.V. PGE, pencil graphite electrode; Au-Pt BNPs, Au-Pt bimetallic nanoparticles; ZDV, zidovudine. …”
Section: Biosensormentioning
confidence: 99%
“… Reprinted with permission from Akbari Hasanjani and Zarei (2021) Copyright 2021 Elsevier B.V. PGE, pencil graphite electrode; Au-Pt BNPs, Au-Pt bimetallic nanoparticles; ZDV, zidovudine. …”
Summary
Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers
.
Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.
“…The study of Akbari Hasanjani and Zarei was also interesting. A modified pencil graphite electrode was made using deoxyribonucleic acid/Au-Pt bimetallic nanoparticles/graphene oxide–chitosan (DNA/Au-Pt BNPs/GO-CS/PGE) for the determination of zidovudine (ZDV), a type of drug broadly employed for the treatment of AIDS ( Figure 9 ) ( Akbari Hasanjani and Zarei, 2021 ). The modified electrode demonstrated a good electrocatalytic activity to the ZDV because of the effect of DNA and the synergetic effects of Au-Pt BNPs and GO-CS.…”
Section: Biosensormentioning
confidence: 99%
“…Furthermore, the modified electrode was successfully utilized to determine ZDV in human serum samples. Figure 9 A schematic of the construction of the DNA/Au-Pt BNPs/GO-CS/PGE electrochemical biosensor for ZDV detection Reprinted with permission from Akbari Hasanjani and Zarei (2021) Copyright 2021 Elsevier B.V. PGE, pencil graphite electrode; Au-Pt BNPs, Au-Pt bimetallic nanoparticles; ZDV, zidovudine. …”
Section: Biosensormentioning
confidence: 99%
“… Reprinted with permission from Akbari Hasanjani and Zarei (2021) Copyright 2021 Elsevier B.V. PGE, pencil graphite electrode; Au-Pt BNPs, Au-Pt bimetallic nanoparticles; ZDV, zidovudine. …”
Summary
Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers
.
Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.
“… 107 Furthermore, according to the results of electrochemical impedance spectroscopy, Pd/Cu NWs could either enhance the conductivity of the electrode interface or facilitate electron transfer, as was also reported by Hasanjani and Zarei. 108 Additionally, bimetallic NWs increased the electroactive surface area compared to the bare GCE. Finally, the biosensor indicated an acceptable reproducibility, and its limit of detection (LOD) was estimated to be 1.5 parts per trillion (ppt).…”
Section: Case Studies Of Bimetallic Nanoparticles In Relation To Sdg ...mentioning
Green synthesized bimetallic nanoparticles may be recognized as key nanotechnological tools to provide disruptive and effective strategies to reach the Sustainable Developments Goals (SDGs).
“…We found that SiNWs/AuNPs nanocomposites could discriminate electrochemical signals with and without the presence of dengue virus gene, making them suitable for use as sensing materials. 3,[15][16][17] Despite limited research on SiNWs in electrochemical DNA detection, their unique features, such as strong conductivity, high biocompatibility, and high surface-to-volume ratio, make them promising for this application. Although we have successfully enhanced DNA probe immobilization on SiNWs/AuNPs modied electrodes, there is room for improvement in biosensor sensitivity and performance.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
