DNA as highly biocompatible carriers for drug delivery

Abstract

This review aims to provide an overview of existing research on the use of various nucleic acid-based nanocarriers for drug delivery and summarize recent advances, including targeting strategies of DNA-based carriers, and the types of drugs that can be incorporated into the carriers.

Multifunctional Ionic Hydrogel-Based Transdermal Delivery of 5-Fluorouracil for the Breast Cancer Treatment

“…Biocompatibility plays a crucial role in terms of drug delivery systems, that is, a drug delivery system with lower biocompatibility leads to effect some normal cells or tissues by itself . We defended this statement by performing the in vitro biocompatibility of both ionic hydrogels on normal cell lines (L-132 cells) as well as two different cancerous cell lines (MCF-7).…”

“…Biocompatibility plays a crucial role in terms of drug delivery systems, that is, a drug delivery system with lower biocompatibility leads to effect some normal cells or tissues by itself. 55 We defended this statement by performing the in vitro biocompatibility of both ionic hydrogels on normal cell lines (L-132 cells) as well as two different cancerous cell lines (MCF-7). As depicted in Figure 7a,b and Table S3, for both ionic hydrogels at different concentration, cell viability of L-132 and MCF-7 cells was greater than 92% for 48 h. This is due to the biocompatible resources used in the formation of ionic hydrogels, such as amino acids and choline, which are essential nutrient for human body.…”

Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery

“…[ 37 ] In addition to the extensively documented double‐helix structures, DNA exhibits a proclivity for adopting non‐canonical configurations, including but not limited to triplexes, hairpins, cruciforms, G‐quadruplexes, and bulges. [ 38 ] Noteworthy advancements have been observed in this domain with the emergence of DNA nanotechnology, culminating in the intricate design and fabrication of nanostructure res such as DNA origami, nanoflowers, cages, nanotubes, and polyhedrons. [ 39 ] These structures not only facilitate effective drug loading through a diverse array of mechanisms but also induce responsive drug release via structural modifications in the DNA framework.…”

Diagnosis and Vulnerability Risk Assessment of Atherosclerotic Plaques Using an Amino Acid-Assembled Near-Infrared Ratiometric Nanoprobe

“…The biocompatibility of nanoprobes is a key factor in determining their in vivo applications. Using bioendogenous materials (e.g., DNA and amino acids) as building blocks is a promising way to prepare nanoprobes with high biocompatibility. , Moreover, it is well known that once an exogenous substance enters the human blood circulation system, the immune system will spontaneously engulf the foreign substance through the mononuclear phagocyte system and quickly expel it from the body. To realize the highly efficient accumulation of a nanoprobe at the atherosclerotic plaque sites, the nanoprobe should have a relatively long blood circulation time.…”