DNA as a target for lanthanide(III) complexes influence

Jastrząb, Renata; Nowak, Martyna; Skrobańska, Monika; Tolińska, Agnieszka; Zabiszak, Michał; Gabryel, Malwina; Marciniak, Łukasz; Kaczmarek, Małgorzata T.

doi:10.1016/j.ccr.2018.12.018

Cited by 63 publications

(27 citation statements)

References 182 publications

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“…Cerium ion is known to promote the hydrolysis of phosphorylated substrates by cleaving the phosphoester bonds. [ 12 ] The as‐synthesized CeNPs with abundant surface cerium ions can be readily internalized into MCs, and directly modulate the intracellular phospho‐signaling cascades to stabilize allergen‐stimulated MCs based on their phosphatase‐mimetic activities. The detailed mechanism for the preventive effect of PMNSs on allergic diseases is elucidated, including the critical role of surface oxygen vacancies, the modulating effect on phospho‐signaling cascades, and the stabilizing effect on allergen‐stimulated MCs.…”

Section: Methodsmentioning

confidence: 99%

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A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease

et al. 2021

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Allergic diseases are pathological immune responses with significant morbidity, which are closely associated with allergic mediators as released by allergen-stimulated mast cells (MCs). Prophylactic stabilization of MCs is regarded as a practical approach to prevent allergic diseases. However, most of the existing small molecular MC stabilizers exhibit a narrow therapeutic time window, failing to provide long-term prevention of allergic diseases. Herein, ceria nanoparticle (CeNP-) based phosphatase-mimetic nano-stabilizers (PMNSs) with a long-term therapeutic time window are developed for allergic disease prevention. By virtue of the regenerable catalytic hotspots of oxygen vacancies on the surface of CeNPs, PMNSs exhibit sustainable phosphatase-mimetic activity to dephosphorylate phosphoproteins in allergen-stimulated MCs. Consequently, PMNSs constantly modulate intracellular phospho-signaling cascades of MCs to inhibit the degranulation of allergic mediators, which prevents the initiation of allergic mediator-associated pathological responses, eventually providing protection against allergic diseases with a long-term therapeutic time window.The prevalence of allergic diseases has increased dramatically to epidemic proportions worldwide. More than 25% of the people worldwide suffer from numerous allergic diseases, [1] including

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Section: Methodsmentioning

confidence: 99%

“…As a result, the phosphatase‐mimetic activity of PMNSs is inhibited under both treatments (Figure 1g), indicating the Ce 3+ and Ce 4+ around the surface oxygen vacancies of PMNSs can bind with H 2 O and P‐Tyr respectively for an SN 2 hydrolysis reaction (Figure 1h). [ 12a,b ]…”

Section: Methodsmentioning

confidence: 99%

A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease

et al. 2021

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“…The lanthanide complexes have been employed in light devices [10][11][12][13][14][15][16][17], solid state lasers [1,2,18], temperature probes [19][20][21] and in the construction of optical signal amplifiers in telecommunication networks [22,23] as well as in biomedical imaging (MRI) fields [24,25]. Moreover, complexes of Pr(III), Er(III) and Yb(III) containing the Schiff base N 2 ,N 3 -bis(anthracen-9ylmethylene)pyridine-2,3-diamine (SBL) showed in vitro cytotoxicity against some human cancer cell lines [26] and the role of Ln(III) complexes to bind, cleavage of DNA also in diagnosis, and monitoring the treatment of cancer disease was recently summarized [27]. In addition to these applications, the presence of large number of unpaired f-electrons and the large intrinsic magnetic anisotropy of the lanthanide compounds [3,[28][29][30][31][32] utilized a useful way in the design of molecular magnetic materials (SMMs) [3,[33][34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization, Magnetic and Luminescent Properties of Praseodymium(III)-4,4,4-Trifluoro-1-(2-Naphthyl)Butane-1,3-Dionato(1-) Complexes

et al. 2021

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Four new Pr(III) mononuclear complexes of formula [Pr(ntfa)3(MeOH)2] (1), [Pr(ntfa)3(bipy)2] (2), [Pr(ntfa)3(4,4`-Mt2bipy)] (3) and [Pr(ntfa)3(5,5`-Me2bipy)] (4), where ntfa = 4,4,4-trifuoro-1-(naphthalen-2-yl)butane-1,3-dionato(1-), 5,5`-Me2bipy = 5,5`-dimethyl-2,2`-dipyridine, 4,4`-Mt2bipy = 4,4′-dimethoxy-2,2`-dipyridine, have been synthesized and structurally characterized. The complexes display the coordination numbers 8 for 1, 3 and 4, and 10 for 2. Magnetic measurements of complexes 1–4 were consistent with a magnetically uncoupled Pr3+ ion in the 3H4 ground state. The solid state luminescence studies showed that the ancillary chelating bipyridyl ligands in the 2–4 complexes greatly enhance the luminescence emission in the visible and NIR regions through efficient energy transfer from the ligands to the central Pr3+ ion; behaving as “antenna” ligands.

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“…Emission of lanthanide(III) ions, e.g., Nd(III), Sm(III), or Yb(III) in the Near-infrared (NIR) region that is detected through animal tissue of considerable thickness, could also be used for imaging in vivo [4]. Additionally, lanthanide(III) compounds are used as antibacterial agents [5][6][7][8] and show very effective catalytic properties with high selectivity for hydrolytic cleavage or transesterification of RNA and as a substance promoting DNA cleavage [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

et al. 2020

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Binary complexes of tartaric acid with lanthanide(III) ions were investigated. The studies have been performed in aqueous solution using the potentiometric method with computer analysis of the data for detection of the complexes set, determination of the stability constants of these compounds. The mode of the coordination of complexes found was determined using spectroscopy, which shows: Infrared, circular dichroism, ultraviolet, visible as well as luminescence spectroscopy. The overall stability constants of the complexes as well as the equilibrium constants of the reaction were determined. Analysis of the equilibrium constants of the reactions and spectroscopic data allowed the effectiveness of the carboxyl groups in the process of complex formation.

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DNA as a target for lanthanide(III) complexes influence

Cited by 63 publications

References 182 publications

A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease

A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease

Structural Characterization, Magnetic and Luminescent Properties of Praseodymium(III)-4,4,4-Trifluoro-1-(2-Naphthyl)Butane-1,3-Dionato(1-) Complexes

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

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