DNA as a Molecular Local Thermal Probe for the Analysis of Magnetic Hyperthermia

Dias, Jorge T.; Moros, María; Pino, Pablo del; Rivera, Sara; Grazú, Valeria; Fuente, Jesús M. de la

doi:10.1002/ange.201305835

Cited by 45 publications

(69 citation statements)

References 17 publications

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“…Reidinger et al have indirectly measured temperatures within 0.5 nm of a MNP surface, and have observed an increase in temperature as high as 45 °C upon application of a high frequency magnetic field at frequency of 334.5 kHz and field strength in the range of 7.2 – 13.5 kA/m *43+. Similar results have been published by Dias et al, where the temperature at 5.6 nm (ten times more than Riedinger et al) away from the MNP surface was found to be 6 °C higher than the bulk fluid temperature [43, 45]. Based on these observations, no major difference would be seen in the fluorescent intensity of RhB-PCL, unless the RhB was located within a few nanometers of MNP surfaces.…”

Section: Resultssupporting

confidence: 89%

“…The local temperature inside the micelle core when subjected to magnetic field is higher than the bulk fluid temperature, but the error in temperature measurement of ± 1.5 °C using the fluoroptic probe implies that this difference may not be significant (Table 2). Also, during this process the temperature inside the core of micelles did not reach hyperthermia conditions over a period of 20 minutes, suggesting that (1) the distance between the fluorophores and the MNP surfaces was larger than few nanometers [43, 45], and (2) that a greater concentration of MNPs inside the micelles may be necessary to reach temperatures needed to melt the micelle cores.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, techniques have been reported to experimentally verify the temperature rise near the MNP surface when subjected to magnetic heating [43–45]. Riedinger et al have shown indirectly using fluorophores attached to MNPs through thermally-labile azo bonds that the local temperature within 0.5 nm of the surface of iron oxide MNPs is much higher (ΔT > 45 °C) than the temperature of bulk fluid [43] during application of a 334.5 kHz, 7 – 13.5 kA/m magnetic field.…”

Section: Introductionmentioning

confidence: 99%

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Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

Shah

Dombrowsky

Paulson

et al. 2016

Materials Science and Engineering: C

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Magnetic iron oxide nanoparticles (MNPs) have been developed for magnetic fluid hyperthermia (MFH) cancer therapy, where cancer cells are treated through the heat generated by application of a high frequency magnetic field. This heat has also been proposed as a mechanism to trigger release of chemotherapy agents. In each of these cases, MNPs with optimal heating performance can be used to maximize therapeutic effect while minimizing the required dosage of MNPs. In this study, the heating efficiencies (or specific absorption rate, SAR) of two types of MNPs were evaluated experimentally and then predicted from their magnetic properties. MNPs were also incorporated in the core of poly(ethylene glycol-b-caprolactone) micelles, co-localized with rhodamine B fluorescent dye attached to polycaprolactone to monitor local, nanoscale temperatures during magnetic heating. Despite a relatively high SAR produced by these MNPs, no significant temperature rise beyond that observed in the bulk solution was measured by fluorescence in the core of the magnetic micelles. MNPs were also incorporated into a macro-scale agarose gel system that mimicked a tumor targeted by MNPs and surrounded by healthy tissues. The agarose-based tumor models showed that targeted MNPs can reach hyperthermia temperatures inside a tumor with a sufficient MNP concentration, while causing minimal temperature rise in the healthy tissue surrounding the tumor.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

Shah

Dombrowsky

Paulson

et al. 2016

Materials Science and Engineering: C

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“…One possible drawback to the photothermal measurements described above is that temperature is measured on the bulk scale and not on the surface of the nanoparticle where the heat is transduced. There are thermometry techniques that can provide this local temperature information, [22][23][24] but these require more complicated sample preparation, making them more challenging to implement. Finally, the measurements described here could easily be combined with other techniques (e.g., photocatalytic degradation) 9 to assess photothermal effects on different processes.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Hybrid Fe<sub>2</sub>O<sub>3</sub>-Au Nanoparticles for Efficient Plasmonic Heating

Murph¹,

Larsen²,

Lascola³

2016

JoVE

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One of the most widely used methods for manufacturing colloidal gold nanospherical particles involves the reduction of chloroauric acid (HAuCl 4 ) to neutral gold Au(0) by reducing agents, such as sodium citrate or sodium borohydride. The extension of this method to decorate iron oxide or similar nanoparticles with gold nanoparticles to create multifunctional hybrid Fe 2 O 3 -Au nanoparticles is straightforward. This approach yields fairly good control over Au nanoparticle dimensions and loading onto Fe 2 O 3 . Additionally, the Au metal size, shape, and loading can easily be tuned by changing experimental parameters (e.g., reactant concentrations, reducing agents, surfactants, etc.). An advantage of this procedure is that the reaction can be done in air or water, and, in principle, is amenable to scaling up. The use of such optically tunable Fe 2 O 3 -Au nanoparticles for hyperthermia studies is an attractive option as it capitalizes on plasmonic heating of gold nanoparticles tuned to absorb light strongly in the VIS-NIR region. In addition to its plasmonic effects, nanoscale Au provides a unique surface for interesting chemistries and catalysis. The Fe 2 O 3 material provides additional functionality due to its magnetic property. For example, an external magnetic field could be used to collect and recycle the hybrid Fe 2 O 3 -Au nanoparticles after a catalytic experiment, or alternatively, the magnetic Fe 2 O 3 can be used for hyperthermia studies through magnetic heat induction. The photothermal experiment described in this report measures bulk temperature change and nanoparticle solution mass loss as functions of time using infrared thermocouples and a balance, respectively. The ease of sample preparation and the use of readily available equipment are distinct advantages of this technique. A caveat is that these photothermal measurements assess the bulk solution temperature and not the surface of the nanoparticle where the heat is transduced and the temperature is likely to be higher.

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“…Riedinger et al demonstrated that the temperature increased to 45 ∘ C within 0.5 nm of MNPs surface when exposed to an AMF (13.5 kA/m, 334.5 kHz) and decreased exponentially with increasing distance [73]. Dias et al observed a high temperature (8.3 ∘ C) at a distance of 5 nm from the nanoparticle (12 nm in diameter) surface under a harsh AMF (25 kA/m, 835.25 kHz); moreover, the temperature rise decreased with distance [74]. From the point of view of these results, the local high temperature around MNPs may damage cell or organelle membrane, resulting in the release of cathepsins [70] from lysosomes in magnetic hyperthermia and then causing cell apoptosis or death.…”

Section: Mechanismsmentioning

confidence: 99%

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

Chen

Wang

et al. 2017

Journal of Nanomaterials

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The interaction of magnetic nanoparticles (MNPs) with various magnetic fields could directly induce cellular effects. Many scattered investigations have got involved in these cellular effects, analyzed their relative mechanisms, and extended their biomedical uses in magnetic hyperthermia and cell regulation. This review reports these cellular effects and their important applications in biomedical area. More importantly, we highlight the underlying mechanisms behind these direct cellular effects in the review from the thermal energy and mechanical force. Recently, some physical analyses showed that the mechanisms of heat and mechanical force in cellular effects are controversial. Although the physical principle plays an important role in these cellular effects, some chemical reactions such as free radical reaction also existed in the interaction of MNPs with magnetic fields, which provides the possible explanation for the current controversy. It is anticipated that the review here could provide readers with a deeper understanding of mechanisms of how MNPs contribute to the direct cellular effects and thus their biomedical applications under various magnetic fields.

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DNA as a Molecular Local Thermal Probe for the Analysis of Magnetic Hyperthermia

Cited by 45 publications

References 17 publications

Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

Multifunctional Hybrid Fe<sub>2</sub>O<sub>3</sub>-Au Nanoparticles for Efficient Plasmonic Heating

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

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