DNA And RNA Cleavage by Metal Complexes

Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex

“…Similarly, a hyperchromic effect ascribed to an external contact or to a partial uncoiling of DNA structure, exposing more bases of DNA may be due to electrostatic binding [29,30]. Such observations have been noticed in present study where a significant hypochromic effect in absorption titrations of DNA with PdBA exposed an intercalation with the base pairs of DNA [28,31] (Figure 5a). The decrease in UV absorption predicted the stronger interactions of PdBA whose intercalating strengths was dependent on size and electron densities of interacting aromatic rings as side arm with an amine group [27][28][29][30].…”

“…In light of this the PdBA were mixed with CT-DNA separately at certain concentration resulted in changes in absorbance. Generally, the hypochromism effect in UV study reveals their intercalative binding strength attributed to an interaction with DNA bases [27,28]. Similarly, a hyperchromic effect ascribed to an external contact or to a partial uncoiling of DNA structure, exposing more bases of DNA may be due to electrostatic binding [29,30].…”

New ternary copper(II) complexes of l-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity

“…The infrared and electronic spectra were recorded on Perkin Elmer Lambda 35 and Perkin Elmer spectrum one 55 spectrophotometers, respectively at 25°C. Magnetic susceptibility data for polycrystalline samples of the complexes were obtained using Model 300 Lewis-coil-force magnetometer of George Associates Inc. (Berkeley, USA) and Hg[Co(NCS) 4 ] was used as a standard. Experimental susceptibility data were corrected for diamagnetic contributions [41].…”

“…Substantial progress has been made during the past few decades to develop metal-based small molecules as DNA foot-printing as well as the therapeutic agents that are capable of binding and cleaving DNA under the physiological condition [1][2][3][4][5][6][7][8][9][10][11][12]. Metal complexes, in this context, with tunable coordination environments and versatile physicochemical properties offer scope for designing and developping highly sensitive diagnostic agents for medicinal applications as exemplified by the chemotherapeutic agents such as cis-platin and bleomycins [13][14][15].…”

Synthesis, structure and DNA interaction of cobalt(III) bis-complexes of 1,3-bis(2-pyridylimino)isoindoline and 1,4,7-triazacyclononane

“…The application of octahedral complexes has permitted the targeting of specific DNA sites by matching the shape, symmetry and functionality of the metal complex to that of the DNA target. There has also been increased interest in the study of metallointercalators, which play an important role in nucleic acids chemistry for their diverse applications such as foot-printing, sequence-specific binding and reactions, new structural probes, and therapeutic agents [2,6,[10][11][12][13][14][15][16][17][18]. Further, the application of these molecules necessitates isolation of structurally analogous complexes with different shapes and electronic properties, investigation of their DNA-binding properties and then the precise understanding of the structural details of their mode of interaction with the target molecule, namely, double helical DNA.…”