“…Today, a range of multi-stimuli-responsive DNA-based hybrid biomaterials that can be used for different biological applications have been developed. 94–97 For example, the addition of an azobenzene moiety can render the DNA hydrogels photoresponsive, and simultaneously, the incorporation of aptamers can make the hybrid system responsive to multiple targeted stimuli through aptamer recognition. 98–101 These modifications add to the ability of DNA-based materials to respond to various stimuli, which has opened doors for the design and fabrication of smart stimuli-responsive materials that can offer excellent clinical and therapeutic properties.…”