DNA- and BSA-binding studies and anticancer activity against human breast cancer cells (MCF-7) of the zinc(II) complex coordinated by 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine

Competitive DNA-Binding Studies between Metal Complexes and GelRed as a New and Safe Fluorescent DNA Dye

“…These results show complexes 5 and 6 cannot compete for DNA-binding sites with GR and their interaction with DNA is external binding. Obtained results from competitive DNA-binding studies between metal complexes with EB [16,[20][21][22] are similar to obtained results with GR (Tables 1 and 2).…”

“…The obtained results for the complex 5 are different [22]. Results indicate that EB has two DNA binding modes, primarily intercalatively and partially groove bound to the DNA.…”

“…Table 1 indicates obtained results from quenching of the emission band of the GR-DNA system at 592 nm with the addition of complexes. Table 2 shows obtained results from quenching of the emission band of the EB-DNA system at 592 nm with the addition of complexes in our previous reported [16,[20][21][22]. Furthermore, the quenching constants (K SV ) are calculated according to the Stern-Volmer equation (Eq.…”

Synthesis of Salicylic Acid Based Mixed Ligand Complexes: Their Protein Binding Affinities and Antimicrobial Activities

“…Thus, the double reciprocal plot of 1/∆A versus 1/[L] is linear and the binding constant can be estimated from the following equation [22][23][24][25][26][27]. 11 Intercept K Slope =…”

Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study

“…EB is a typical mutagenic intercalating dye for DNA and it has been studied for many years. The significant quenching of the DNA-EB fluorescence suggests that the complex can compete for DNA-binding sites with EB and displace EB from the DNA-EB system, which is usually characteristic of the intercalative interaction of compounds with DNA (Anjomshoa et al, 2014;Tian et al, 2014).…”