DNA analysis of HLA–DR and DQ genes in american blacks with systemic lupus erythematosus

Reveille, John D.; Schrohenloher, Ralph E.; Acton, Ronald T.; Barger, Bruce O.

doi:10.1002/anr.1780321009

Cited by 50 publications

(20 citation statements)

References 35 publications

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“…We did, however, find a significantly increased frequency of the broad specificity HLA- We have previously shown an increased frequency of HLA-DRw8 in American blacks with young-onset SLE (12). In the present study, we also found an increased frequency of HLA-DRw8 in younger black patients with SLE (Table 3); however, the difference did not reach statistical significance.…”

Section: Resultscontrasting

confidence: 88%

“…As has been shown previously (12,22), anti-U1 RNP and anti-Sm antibodies were found more frequently in American blacks than in Caucasians. A finding not reported previously, however, was that the significantly increased frequency of anti-RNP antibodies in the black patient population (when compared with age-matched Caucasian patients) was due to the marked increase among those <I8 years of age.…”

Section: Discussionsupporting

confidence: 83%

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Clinical, serologic, and immunogenetic studies in childhood‐onset systemic lupus erythematosus

Barron

Silverman

Gonzales

et al. 1993

Arthritis & Rheumatism

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125

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Objective. To determine the frequency of systemic lupus erythematosus (SLE)-associated clinical manifestations, autoantibodies, and HLA class I1 alleles in a large cohort of patients with childhood-onset SLE.Methods. Eighty children with SLE onset before age 18 (27 before age 11) were studied for the frequency of renal, neuropsychiatric, and hematologic complications as well as for anti-native DNA, Ro, La, Sm, and U1 RNP autoantibodies. HLA-DR, DQ, and DP alleles were determined by oligotyping. The results were compared with findings in 213 adults with SLE onset at or after age 18 years.Results. Renal involvement was more frequent in those with childhood-onset SLE, especially those with onset before age 11 (82%, compared with 53% in adults). Anti-U1 RNP was more common in American blacks with SLE onset before age 18. HLA-DRB1*0301, DQA1*0501, DQB1*0201 was more common in Cau-

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Section: Resultscontrasting

confidence: 88%

Section: Discussionsupporting

confidence: 83%

Clinical, serologic, and immunogenetic studies in childhood‐onset systemic lupus erythematosus

Barron

Silverman

Gonzales

et al. 1993

Arthritis & Rheumatism

Self Cite

125

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“…Reveille et al showed that early onset SLE patients ((20 years old) have a high frequency of HLA-DRw8, 21 and Manger et al reported that SLE patients with Fcc IIA-R/R131 and IIA/IIIA-R/R131, F/F158 polymorphisms have a younger onset of disease. 22 However, the number of early onset SLE subjects was very small (18 patients in the former study), or not mentioned.…”

Section: Discussionmentioning

confidence: 99%

Association of the oestrogen receptor gene polymorphisms with disease onset in systemic lupus erythematosus

Lee¹,

Shin²,

Kang

et al. 2004

Annals of the Rheumatic Diseases

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Objective: To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor a (ORa) in patients with systemic lupus erythematosus (SLE) in Korea. Methods: Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and XbaI restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups. Results: Although the Pp genotype occurred more often in SLE patients than in controls (p c = 0.017), ORa genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (p c = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p c = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (p c = 0.0009) or adult onset SLE (p c = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. Conclusions: ORa polymorphisms are significantly associated with the age at disease onset in Koreans with SLE. S ystemic lupus erythematosus (SLE) is an idiopathic systemic inflammatory disease with diverse manifestations. Although the aetiopathology of SLE is not clearly understood, sex hormones are considered to affect the pathogenic mechanism. Epidemiologically, a female predominance is consistently demonstrated-about 90% of adult SLE patients are female. The peak incidence of SLE occurs in the reproductive period, and a postmenopausal onset of SLE is relatively uncommon. 1 Experimentally, the progression of lupus and mortality are different in female and male mice, and exogenous oestrogen reduces longevity and accelerates nephritis in the NZB/NZW lupus model.

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“…HLA-DR and -DQ specificities were assigned to specific RFLP bands at the 10th International Histocompatibility Testing Workshop (24), as well as in our own (25,26) and others' studies (27-32). Specific DQA1 and DQB1 chain alleles in each individual were assigned by comparison with reported DQA1 and DQB1 RFLP's for specific HLA-D haplotypes as determined by the World Health Organization Nomenclature Committee for factors of the HLA system which met during the 7th International Congress of Immunology in 1989 (33).…”

Section: Methodsmentioning

confidence: 99%

Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.

Arnett¹,

Olsen²,

Anderson³

et al. 1991

J. Clin. Invest.

113

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Autoantibodies to phospholipids (APA) occur frequently in systemic lupus erythematosus (SLE) and other autoimmune disorders and predispose to intravascular thromboses. Major histocompatibility complex (MHC) class II alleles (HLA-DR and DQ) were determined by restriction fragment length polymorphisms (RFLP) in 20 patients with APA (lupus anticoagulant). HLA-DQw7 (DQB1 *0301), linked to HLA-DR5 and -DR4 haplotypes, occurred in 70% and was significantly increased compared to 139 race-matched normal controls (P = 0.002, P corrected Ipci = 0.05, odds ratio [OR] = 5.1). Moreover, the frequency of HLA-DQw7 was significantly higher in SLE patients with APA as compared with patients without APA but with other autoantibodies, including anti-Ro and La (P = 0.0001, pc = 0.002, OR = 10.7), anti-Ro alone (P = 0.001, pc = 0.02, OR = 11.2), anti-dsDNA (P = 0.001, pc = 0.02, OR = 7.1), and possibly anti-Sm (P = 0.04, pc = NS, OR = 6.8) and anti-nRNP (U1-RNP) (P = 0.01, pc = NS, OR = 7.8). The DQB1 *0301 allele of DQw7 showed the strongest association, while the frequencies of the DQA1 *0301 (45%) and DQA1 *0501 (50%) alleles did not differ from the controls. Among the HLA-DQB1

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DNA analysis of HLA–DR and DQ genes in american blacks with systemic lupus erythematosus

Cited by 50 publications

References 35 publications

Clinical, serologic, and immunogenetic studies in childhood‐onset systemic lupus erythematosus

Clinical, serologic, and immunogenetic studies in childhood‐onset systemic lupus erythematosus

Association of the oestrogen receptor gene polymorphisms with disease onset in systemic lupus erythematosus

Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant.

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