DNA adducts in human placenta as related to air pollution and to GSTM1 genotype

Topinka, Jan; Binková, Blanka; Mračková, Gabriela; Stávková, Zdena; Beneš, I; Dejmek, J; Leníček, Jan; Šrám, Radìm J.

doi:10.1016/s0165-1218(96)00166-8

Cited by 61 publications

(28 citation statements)

References 28 publications

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“…Traffic jams are frequent at site 3, lasting up to 2 h (http://www.jb.com.br/rio/noticias) and subjecting bus drivers to a risk of exposure of up to 0.69 ng/m 3 benzo(a)pyrene. This concentration is above the USEPA limit, and several studies have demonstrated an increase in DNA adducts at this level (Topinka et al, 1997;Lewtas et al, 1997;Kyrtopoulos et al, 2001). …”

Section: Risk Assessmentmentioning

confidence: 87%

Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil

Rainho¹,

Velho²,

Corrêa³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Risk assessment can provide a comprehensive estimate of potential effects of contaminants under specific, well-defined, and well-described circumstances, providing quantitative relationships between exposure and effects to identify and to define areas of concern. We investigated the mutagenic activity of particulate matter in air samples collected from three sites in Rio de Janeiro city. Samples were collected using a high-volume sampler at Avenida Brasil, at Campus of Universidade do Estado do Rio de Janeiro, and at Rebouças Tunnel. Six polycyclic aromatic hydrocarbons were quantified by gas chromatography/mass spectrometry. Salmonella typhimurium TA98 and the derivative strains TA98/1.8-DNP 6 , YG1021, and YG1024, Health risk in urban airborne in Rio de Janeiro commonly used in mutagenicity assays, were treated (10-50 µg/plate), with and without exogenous metabolization. The highest values for the polycyclic aromatic hydrocarbons were detected at Rebouças Tunnel. For chrysene, as an example, the concentration was nearly 200 times higher than that established by the US Environmental Protection Agency. Frequent traffic jams can place bus drivers who go through the Rebouças Tunnel at risk of exposure to up to 0.69 ng/m 3 benzo(a) pyrene. Independent of exogenous metabolization, mutagenicity was detected in strains YG1021 and YG1024 at all the sites, suggesting nitro and amino derivatives of polycyclic aromatic hydrocarbons. Rebouças Tunnel air samples gave the highest values for rev/µg and rev/m 3 . This could be due to the fact that the long, enclosed passageway through a mountain restricts ventilation. The cancer risk estimate in this study was 10 -3 for the benzo(a)pyrene, at the two sites, indicating a high risk.

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Section: Risk Assessmentmentioning

confidence: 87%

Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil

Rainho¹,

Velho²,

Corrêa³

et al. 2013

Genet. Mol. Res.

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“…In an analysis of environmentally exposed populations, effects of genotypes on DNA adducts from lung tissue of autopsy donors (58,59) and from placentas of mothers living in an air-polluted region were found (75). GSTMI-null genotype increased the affected mutagenicity of urine in smokers (61) and in subjects from polluted regions (76).…”

Section: Discussionmentioning

confidence: 99%

Effect of Glutathione S-Transferase M1 Polymorphisms on Biomarkers of Exposure and Effects

Šrám¹

1998

Environmental Health Perspectives

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Genotypes responsible for interindividual differences in ability to activate or detoxify genotoxic agents are recognized as biomarkers of susceptibility. Among the most studied genotypes are human glutathione transferases. The relationship of genetic susceptibility to biomarkers of exposure and effects was studied especially in relation to the genetic polymorphism of glutathione S-transferase Ml (GSTM1). For this review papers reporting the effect of GSTM1 genotype on DNA adducts, protein adducts, urine mutagenicity, Comet assay parameters, chromosomal aberrations, sister chromatid exchanges (SCE), micronuclei, and hypoxanthine-guanine phosphoribosl transferase mutations were assessed. Subjects in groups occupationally exposed to polycyclic aromatic hydrocarbons, benzidine, pesticides, and 1,3-butadiene were included. As environmentally exposed populations, autopsy donors, coal tar-treated patients, smokers, nonsmokers, mothers, postal workers, and firefighters were followed. From all biomarkers the effect of GSTM1 and N-acetyl transferase 2 was seen in coke oven workers on mutagenicity of urine and of glutathione S-transferase Ti on the chromosomal aberrations in subjects from 1,3-butadiene monomer production units. Effects of genotypes on DNA adducts were found from lung tissue of autopsy donors and from placentas of mothers living in an air-polluted region. The GSTM1 genotype affected mutagenicity of urine in sm6kers and subjects from polluted regions, protein adducts in smokers, SCE in smokers and nonsmokers, and Comet assay parameters in postal workers.

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“…According to Dejmek et al (2000), the risk of delivering a growth-retarded infant increases with the level of PAHs in early gestation (first month) [53]. A bond of benzopyrene and DNA in the placenta, has an influence on intrauterine growth retardation -IUGR [54,55]. The exposure to particulate matter (PM) causes increase of risk of occurrence an intrauterine fetus growth retardation [56,57,58].…”

Section: The Adverse Effects Of Air Pollution On Pregnancy Outcomes Amentioning

confidence: 99%

Impact of Air Pollution on Public Health

Marchwińska-Wyrwał¹,

Dziubanek²,

Hajok³

et al. 2011

The Impact of Air Pollution on Health, Economy, Environment and Agricultural Sources

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DNA adducts in human placenta as related to air pollution and to GSTM1 genotype

Cited by 61 publications

References 28 publications

Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil

Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil

Effect of Glutathione S-Transferase M1 Polymorphisms on Biomarkers of Exposure and Effects

Impact of Air Pollution on Public Health

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