“…Apiole (3) was less studied, but nevertheless showed also a wealth of biological activities, such as antifungal (Meepagala et al, 2005;Razzaghi-Abyaneh et al, 2007), antioxidant (Zhang et al, 2006), phytotoxic (Meepagala et al, 2005) and an even more potent synergistic insecticide potential than 2 (Lichtenstein et al, 1974). In fact, in most of the studies where 2 and 3 or 4 were compared regarding their biological activities, 3 and 4 were more potent than 2 (Lichtenstein et al, 1974;Zhang et al, 2006;RazzaghiAbyaneh et al, 2007), while unwanted carcinogenic and genotoxic properties (well established for safrole and estragole) decreased with further methoxylations of the aromatic nucleus in the order: safrole > 2 > 3 > 4 (Zhou et al, 2007). Only one study recently explored the biological activity of a nothoapiole containing mixture through the evaluation of the antioxidant, antibacterial and antifungal properties of Carum nigrum essential oil and oleoresin (Singh et al, 2006), but this substance was contained in low percentage in these mixtures and was not evaluated alone.…”