DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

Gerhards, Martin; Böhme, Alexander; Schubert, Kristin; Kodritsch, Bernhard; Ulrich, Nadin

doi:10.1016/j.crtox.2022.100097

Cited by 1 publication

(1 citation statement)

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“…When metabolized into benzo[a]pyrene-7,8-diol-9,10epoxide, it can bind to DNA, leading to the creation of DNA adducts. These adducts can introduce mistakes during DNA replication and repair processes, ultimately elevating the risk of cancer [305]. In a study conducted by Zahin et al [306], EA significantly decreased number of BaP-induced DNA adducts.…”

Section: Ellagic Acid and Genome Instability And Mutationmentioning

confidence: 99%

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Čižmáriková,

Michalková,

Mirossay

et al. 2023

Biomolecules

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Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease.

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Section: Ellagic Acid and Genome Instability And Mutationmentioning

confidence: 99%