DMSO protects against adriamycin-induced tissue necrosis

Lebredo, Luis; Barrie, Rosemary; Woltering, Eugene A.

doi:10.1016/0022-4804(92)90014-q

Cited by 39 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SOD reduces the superoxide radical (O 2 -), GSH-Px and catalase inactivate H 2 O 2 and the hydroxyl radical (OH W ) [8,9,22]. The antioxidant agent DMSO used in this experiment specifically scavenges the superoxide radical and has low cellular toxicity [26,27].…”

Section: Discussionmentioning

confidence: 99%

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

Küçük¹,

Sözüer²,

Ikizceli³

et al. 2003

Eur Surg Res

View full text Add to dashboard Cite

Obstructive jaundice is associated with high morbidity and mortality. Major complications such as pulmonary dysfunction, renal failure and sepsis are frequently encountered. Recent studies and observations suggest that the free oxygen radicals (FORs) produced in obstructive jaundice may play a significant role in the etiopathogenesis of acute renal failure (ARF). Thirty rats were divided into three groups, as sham, control and treatment groups containing 10 rats each. Laparatomy was performed on each animal in the control and treatment groups and common bile ducts were ligated. Common bile duct was observed but was not ligated for the rats in the sham group. Saline solution injection was begun on the first day of surgical procedure and repeated once a day during the following 5 days. The same procedure was performed with oxygen radical scavenger dimethyl sulfoxide (1.5 mg/kg/day i.p.) instead of saline in the treatment group. The rats were sacrificed on the 7th postoperative day. On the 7th postoperative day, the bilirubin, urea and creatinine levels of the control and treatment groups were significantly higher in comparison with the sham group (p < 0.01). Although there was no statistically significant difference between the bilirubin levels of the control and treatment groups (p > 0.05), the urea and creatinine levels in the treatment group were significantly lower (p < 0.01). On the 7th postoperative day, the erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels of the control and treatment groups were significantly lower than those of the sham group (p < 0.01), whereas renal and erythrocyte malondialdehyde (MDA) levels were significantly higher (p < 0.01). Although SOD and GSH-Px levels did not differ significantly between the treatment and control groups (p > 0.05), renal and erythrocyte MDA levels of the treatment group were significantly lower than those of the control group (p < 0.01). The histopathological scores were significantly higher in the control and treatment groups (p < 0.01); there was no significant difference between the control and treatment groups (p > 0.05). FORs seem to play a significant role in the etiopathogenesis of renal failure in obstructive jaundice. Antioxidant treatment may decrease oxidative damage due to FORs and may prevent renal failure.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

Küçük¹,

Sözüer²,

Ikizceli³

et al. 2003

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…Surgical excision has been proposed for both ulcer prevention and treatment of established ulcers [21]. The exact mechanisms of action by which doxorubicin causes the local tissue necrosis is unknown, thus (bio)chemical interventions have focused on both trying to reduce local inflammation (e.g., by administration of steroids or dapsone) and prevention and scavenging free radicals (e.g., by administration of DMSO) [2,9,10,[12][13][14][15][16][17][18][19]21].…”

Section: Discussionmentioning

confidence: 99%

“…The backs of the animals were shaved. One milliliter of a 2 mg/ml solution of doxorubicin hydrochloride was injected intradermally with a 25-gauge needle into the tissue 3 cm lateral to the spine [12][13][14][15][16]. A gloved finger was placed over the injection site for 30 sec to prevent any fluid from escaping from the injection site.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Use of subatmospheric pressure to prevent doxorubicin extravasation ulcers in a swine model

et al. 1999

View full text Add to dashboard Cite

Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. Background and Objectives Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic ulcers, which usually progress and expose underlying structures such as tendons and bone. The exact mechanism of action that causes cell death and the chronic ulcers is unknown. Methods Eight sites were injected intradermally with doxorubicin on each of 4 pigs. Four sites on each animal served as untreated controls. The remaining four sites were exposed to 125 mm Hg subatmospheric pressure applied 1 h after injection. The sites were observed on a three times per week schedule. Sites that did not develop ulcers were re‐injected up to a total of four injections. The animals were observed for 5 weeks. Results Ten of sixteen control sites developed ulcers. No subatmospheric pressure treated sites developed ulcers. The incidence of ulcer formation was significantly less for treated wounds compared to control wounds at P < 0.001 by Fisher's exact test. Conclusions This physical modality appears to successfully prevent ulcer formation after doxorubicin injection. J. Surg. Oncol. 1999;72:14–17. © 1999 Wiley‐Liss, Inc.

show abstract

“…People who have it on hand often use it for minor cuts and burns and report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns [13][14][15][16]. In relation to cancer, several properties of DMSO have gained attention.…”

Section: Introductionmentioning

confidence: 99%

Effect of Maxima Suppressor and Supporting Electrolyte on Polarographic Wave of Dimethyl Sulfoxide and its Determination

Gupta¹

2016

Med chem

View full text Add to dashboard Cite

The oxidation of the biologically very important dimethyl sulfoxide system has been the subject of investigations. In present study Dimethyl sulfoxide (DMSO) can be oxidized to dimethyl sulfone by anodic electrolysis at a rotating platinum electrode. The polarographic method has been used to study qualitatively the effect of maxima suppressor gelatin, fuchsin, methyl red, thymol blue and supporting electrolyte HCl, CH 3 COOH on oxidation wave of DMSO. Polarographic oxidation of DMSO in 0.1 M HCl, 0.1 M CH 3 COOH solution using optimum concentration of fuchsin, methyl red, thymol blue as surface active substances is followed to determine the DMSO present in synthetic sample by calibration method. Wave analysis indicate the irreversible nature of the oxidation process which involves oxidation of dimethyl sulfoxide to dimethyl sulfone thereby increasing the oxidation state of sulphur from +2 to +4 state.

show abstract

DMSO protects against adriamycin-induced tissue necrosis

Cited by 39 publications

References 21 publications

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

Use of subatmospheric pressure to prevent doxorubicin extravasation ulcers in a swine model

Effect of Maxima Suppressor and Supporting Electrolyte on Polarographic Wave of Dimethyl Sulfoxide and its Determination

Contact Info

Product

Resources

About