DMSA and its complexes with radioisotopes: review

Staník, R.; Svêtlík, Jan; Benkovský, I.

doi:10.1007/s10967-012-1743-9

Cited by 9 publications

(4 citation statements)

References 132 publications

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“…Moreover, small changes in preparation procedures can cause differences in the formation of different types of products and lead to differences in their biodistribution (14). Therefore, procedures for kit preparation and injection were studied and standardized in this study, with the kits prepared in the same manner and following the manufacturer's instructions.…”

Section: Initiation Of This Study Was Based On Clinical Observation O...mentioning

confidence: 99%

Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Bulushi

Nabhani

Shetty

et al. 2022

J. Nucl. Med. Technol.

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Section: Initiation Of This Study Was Based On Clinical Observation O...mentioning

confidence: 99%

Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Bulushi

Nabhani

Shetty

et al. 2022

J. Nucl. Med. Technol.

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“…In contrast to Dimercaprol, DMSA is less toxic, much more soluble in water, and hence has limited solubility in lipids, and is effective when taken orally (10 mg kg −1 per day in adult). The use of DMSA in decorporation of heavy metal poisoning has been examined, specifically for mobilising inorganic mercury, cadmium, arsenic, copper, lead, gold and antimony [30,34,[47][48][49][50].…”

Section: Examples Of Drugs Currently Used In Decorporation Treatmentmentioning

confidence: 99%

Treatment of radiological contamination: a review

Bodin¹,

Ménétrier²

2021

J. Radiol. Prot.

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After nuclear accidents, people can be contaminated internally via ingestion, inhalation and via intact skin or wounds. The assessment of absorbed, committed doses after internal exposure is based on activity measurement by in vivo or in vitro bioassay. Estimation of dose following internal contamination is dependent on understanding the nature and form of the radionuclide. Direct counting methods that directly measure γ-rays coming from within the body or bioassay methods that measure the amount of radioactive materials in urine or feces are used to estimate the intake, which is required for calculating internal exposure doses. The interpretation of these data in terms of intake and the lifetime committed dose requires knowledge or making assumptions about a number of parameters (time, type of exposure, route of the exposure, physical, biological and chemical characteristics) and their biokinetics inside the body. Radioactive materials incorporated into the body emit radiation within the body. Accumulation in some specific organs may occur depending on the types of radioactive materials. Decorporation therapy is that acceleration of the natural rate of elimination of the contaminant will reduce the amount of radioactivity retained in the body. This article presents an overview of treatment of radiological contamination after internal contamination.

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“…Both thiomalic acid (H 3 thiomal) and 2,3‐dimercaptosuccinic acid (H 4 dmsa) (Figure 1) are used in medicine. Sodium aurothiomalate is effective for the treatment of rheumatoid arthritis,25 and the most relevant dmsa 4– complexes are currently used as diagnostic agents in nuclear medicine 26. Oxovanadium(IV) was found to form mono and bis complexes with H 3 thiomal and H 4 dmsa, furthermore, with dmsa 4– the formation of [VO(dmsa)] n oligomers was also detected 9.…”

Section: Introductionmentioning

confidence: 95%

Complex Formation between [(η⁶‐p‐cymene)Ru(H₂O)₃]²⁺ and Hydroxycarboxylates or their Sulfur Analogues – The Role of Thiolate Groups in Metal Ion Binding

et al. 2014

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The interactions between [(η 6 -p-cymene)Ru(H 2 O) 3 ] 2+ and Lmalic acid (H 2 mal), L-tartaric acid (H 2 tart), and their sulfurcontaining analogues DL-thiomalic acid (H 3 thiomal) and meso-2,3-dimercaptosuccinic acid (H 4 dmsa) were studied by pH potentiometry, NMR spectroscopy, and ESI-MS. The hydroxycarboxylates are potent metal ion binders and prevent hydrolysis at pH 7.4 in aqueous solution. Although H 2 mal forms mononuclear complexes with different degrees of protonation by the involvement of the alcohol/alkoxide group in addition to the carboxylate groups, the presence of [a]

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DMSA and its complexes with radioisotopes: review

Cited by 9 publications

References 132 publications

Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Treatment of radiological contamination: a review

Complex Formation between [(η⁶‐p‐cymene)Ru(H₂O)₃]²⁺ and Hydroxycarboxylates or their Sulfur Analogues – The Role of Thiolate Groups in Metal Ion Binding

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DMSA and its complexes with radioisotopes: review

Cited by 9 publications

References 132 publications

Abnormal Biologic Distribution Related to Normal Saline Among99mTc-Dimercaptosuccinic Acid Scans

Abnormal Biologic Distribution Related to Normal Saline Among99mTc-Dimercaptosuccinic Acid Scans

Treatment of radiological contamination: a review

Complex Formation between [(η6‐p‐cymene)Ru(H2O)3]2+ and Hydroxycarboxylates or their Sulfur Analogues – The Role of Thiolate Groups in Metal Ion Binding

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Product

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Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Abnormal Biologic Distribution Related to Normal Saline Among^99mTc-Dimercaptosuccinic Acid Scans

Complex Formation between [(η⁶‐p‐cymene)Ru(H₂O)₃]²⁺ and Hydroxycarboxylates or their Sulfur Analogues – The Role of Thiolate Groups in Metal Ion Binding