DLPFC Transcriptome Defines Two Molecular Subtypes of Schizophrenia

Abstract

The Clinical Brain Disorders Branch of the Intramural Research Program at the National Institutes of Health assembled a large collection of frozen post-mortem human brains from individuals diagnosed with schizophrenia and other psychiatric diagnoses, as well as matched control individuals. Illumina HumanHT-12 v4 expression array data was collected from dorsolateral prefrontal cortex (DLPFC) and the data deposited at dbGaP (Study ID: phs000979). We report an analysis of the data from the 189 adult schizophrenics and 206 adult controls in that cohort.