DLPFC stimulation alters working memory related activations and performance: An interleaved TMS-fMRI study

Webler, Ryan; Fox, James; McTeague, Lisa M.; Burton, Philip; Dowdle, Logan T.; Short, E. Baron; Borckardt, Jeffrey J.; Li, Xingbao; George, Mark S.; Nahas, Ziad

doi:10.1016/j.brs.2022.05.014

Cited by 21 publications

(8 citation statements)

References 53 publications

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“…Previous studies have shown that TMS within the DLPFC increases activity within CEN and decreases activity within the oppositely correlated Default Mode Network (DMN). The DMN is primarily composed of the dorsal medial prefrontal cortex (mPFC), PCC/PCu, and angular gyrus and is responsible for slow-flowing thoughts, which may explain the improvement in working memory obtained in our study ( 38 ).…”

Section: Discussionmentioning

confidence: 64%

“…Finally, it is worth noting that the study did not assess mood before and after stimulation (but it did measure the presence of depressive symptoms, to exclude subjects whose cognitive impairment may have resulted from depressive disorders). Since the left DLFPC is also stimulated in depression treatment protocols using rTMS ( 18 , 38 , 47 ) we cannot rule out that to some extent the improvement in working memory performance may have been related to the mood improvement.…”

Section: Discussionmentioning

confidence: 99%

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Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation – a randomized controlled pilot study

Senczyszyn,

Szcześniak,

Wieczorek

et al. 2023

Front. Psychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that could improve cognitive function. It is being developed as a non-pharmacological intervention to alleviate symptoms of cognitive deterioration. We assessed the efficacy of rTMS in improving cognitive functioning among people with Mild Cognitive Impairment (MCI) in a partially-blinded, sham-controlled randomized trial. Out of 91 subjects screened, 31 participants with MCI (mean age 70.73; SD = 4.47), were randomly assigned to one of three groups: (A) Active rTMS; (B) Active rTMS with Computerized Cognitive Training RehaCom; and (C) Sham control. The study evaluated cognitive function using the DemTect, FAS, and CANTAB tests before and after the stimulation. The following treatment protocol was applied: 2000 pulses at 10 Hz, 5-s train duration, and 25-s intervals at 110% of resting MT delivered over the left Dorsolateral Prefrontal Cortex (DLPFC) five times a week for 2 weeks. After 10 sessions of high-frequency rTMS, there was an improvement in overall cognitive function and memory, assessed by the DemTect evaluation, with no serious adverse effects. Analysis of differences in time (after 10 sessions) between studied groups showed statistically significant improvement in DemTect total score (time by group interaction p = 0.026) in favor of rTMS+RehaCom. The linear regression of CANTAB Paired Associates Learning revealed significant differences in favor of rTMS+RehaCom in three subtests. Our study shows that 10 sessions of rTMS over the left DLPFC (alone as well as combined with Computerized Cognitive Training) can have a positive impact on cognitive function in people with MCI. Further research should investigate the underlying mechanism and determine the optimal parameters for rTMS, which will be important for its efficacy in clinical settings.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation – a randomized controlled pilot study

Senczyszyn,

Szcześniak,

Wieczorek

et al. 2023

Front. Psychiatry

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“…The interaction pattern of the lOFC was not the same as those of the mOFC. We found that the lOFC interacted with the dorsal prefrontal cortex and frontal polar cortex, which are believed to be associated with working memory (Potkin et al, 2009;Webler et al, 2022) and to represent retrieved task rules (Mansouri et al, 2020). In addition, the lOFC also interacted with the opercular cortex and dorsal anterior cingulate cortex, which collectively work as the cingulo-opercular network and are related to…”

Section: Mofc and Lofc Updated The Behavior Through Distinct Function...mentioning

confidence: 82%

Differential roles of the medial and lateral orbitofrontal cortex in decision-making

Qiu

Qiu²,

Liao³

et al. 2023

Preprint

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Inferring potential outcomes and updating behavior are prerequisites for making flexible decisions. These abilities are highly associated with the functions of the orbitofrontal cortex (OFC). Previous studies proposed that the lateral OFC (lOFC) infers the potential outcomes and the medial OFC (mOFC) encodes the general information to guide behavior. However, recent works suggested that both these two subregions responded to the same decision-related variable. Therefore, the exact roles of mOFC and lOFC in decision-making remain unclear. To study this issue, we conducted an inference-based decision-making experiment combining with functional magnetic resonance imaging techniques. Here we found that both the mOFC and lOFC represented the inferred outcomes, but only the lOFC was responsible for the outcome inference. Although the inferred outcomes were decodable in both subregions, the outcome in the mOFC was context-general coding, whereas it was context-specific in lOFC. Moreover, the functional coupling analysis showed that the mOFC may update behavior through sensory mediation and motor execution, whereas the lOFC may update behavior through task rule retrieving, alertness maintaining, and motor planning. We concluded that the OFC subregions may be collectively activated in decision-making, but their exact roles can be dissociable.

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“…The MFG and the IFG have been shown to be important brain regions in the DLPFC, which is highly associated with cognitive control functions ( McEwen & Morrison, 2013 ). The DLPFC region was significantly activated while individuals performed the TNT task, so as to recruit sufficient psychological resources to intentionally suppress unwanted memories ( Webler et al, 2022 ; Weidler et al, 2022 ). However, the activation in DLPFC is downregulated under the influence of acute stress, which further impairs memory suppression performance ( McEwen & Morrison, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Acute stress impairs intentional memory suppression through aberrant prefrontal cortex activation in high trait ruminators

Long,

Peng,

et al. 2024

International Journal of Clinical and Health Psychology

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DLPFC stimulation alters working memory related activations and performance: An interleaved TMS-fMRI study

Cited by 21 publications

References 53 publications

Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation – a randomized controlled pilot study

Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation – a randomized controlled pilot study

Differential roles of the medial and lateral orbitofrontal cortex in decision-making

Acute stress impairs intentional memory suppression through aberrant prefrontal cortex activation in high trait ruminators

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