DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε
Huasong Chang,
Hao Wu,
Peili Hou
et al.
Abstract:Discs large membrane-associated guanylate kinase (MAGUK) scaffold protein 1 (DLG1) plays important roles in cell contact and migration, but its role in antiviral innate immunity is not clear. In this study, the role of DLG1 in the antiviral innate immune response and its impact on type-I interferon (IFN-I) signaling were investigated. DLG1 plays a critical role in promoting the IFN-I response by inhibiting the autophagic degradation of the innate immune adaptor IκB kinase epsilon (IKKε). As a result, DLG1 effe… Show more
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