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Toussaint, Jean‐François; Peix, Amalia; Lavergne, Thomas; Vicente, Françoise; Froissart, Marc; Alonso, Christine; Kolář, Petr; Heuzey, J.-Y. Le; Guize, L; Paillard, Michel

doi:10.1023/a:1014681314034

Cited by 16 publications

(5 citation statements)

References 17 publications

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“…Various studies have assessed the feasibility of ERNA in assessing mechanical synchrony and have also validated the accuracy of the method. [19202122] However, to make this technique proceed from the bench to the bedside, we compared and correlated ERNA with the modality, the cardiologist is most familiar with, that is, the echocardiography. To the best of our knowledge, this is the first study comparing ERNA and STE for the assessment of LV mechanical dyssynchrony.…”

Section: Discussionmentioning

confidence: 99%

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Equilibrium radionuclide angiography in evaluation of left ventricular mechanical dyssynchrony in patients with dilated cardiomyopathy: Comparison with electrocardiographic parameters and speckle-tracking echocardiography

et al. 2019

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Purpose of the Study: The purpose of this study was to study the role of equilibrium radionuclide angiography (ERNA) in the assessment of left ventricular (LV) mechanical dyssynchrony in patients with dilated cardiomyopathy (DCM), by correlating the findings with electrocardiographic parameters and speckle-tracking echocardiography (STE). Methods: This was a prospective observational study. A total of 55 patients with a mean age 42.5 ± 11 years (range: 19–61 years) diagnosed with DCM underwent ERNA and echocardiography sequentially. On ERNA, phase images of LV were obtained, and standard deviation of LV mean phase angle (SD LVmPA) was derived to quantify intra-LV mechanical dyssynchrony (ILVD). Similarly, on STE, “dyssynchrony index” was calculated as the standard deviation of time-to-peak systolic circumferential strain (SDCS) of the six mid-LV segments. The cutoff values used to define mechanical dyssynchrony were SD LVmPA >13.2° (or >27.1 ms) and SDCS >74 ms on ERNA and STE, respectively. The results obtained from the two modalities were then compared. Results: Speckle-tracking analysis could be done on the echocardiographic data of only 42 patients. Paired data from ERNA and STE studies of these 42 patients (26 males and 16 females) were compared, which showed no significant difference in the detection of ILVD ( P = 0.125). The two modalities showed good agreement with Cohen's kappa value of 0.78 ( P < 0.0001). SD LVmPA and SDCS values showed moderately strong linear correlation (ρ = 0.69; P < 0.0001). No significant association of mechanical dyssynchrony on ERNA or STE was found with QRS duration and with the presence or absence of left bundle branch block. ILVD was also found to be negatively correlated with LV ejection fraction. Conclusion: ERNA is comparable to STE for the assessment of LV mechanical dyssynchrony.

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Section: Discussionmentioning

confidence: 99%

“…[17] Using phase analysis, ERNA has also been investigated for the assessment of dyssynchronous cardiac contraction, and it is proven to be highly reproducible. [18192021] Being noninvasive, highly reproducible, and relatively easy to perform, it may be one of the most promising techniques to quantify dyssynchrony.…”

Section: Introductionmentioning

confidence: 99%

Equilibrium radionuclide angiography in evaluation of left ventricular mechanical dyssynchrony in patients with dilated cardiomyopathy: Comparison with electrocardiographic parameters and speckle-tracking echocardiography

et al. 2019

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“…The standard deviation of the pixels' phase angles measured in each ventricular Region of Interest (ROI) represents intraventricular dyssynchrony and the difference between the means of the phase angles of both ventricular ROI represents interventricular dyssynchrony [24]. Several studies have reported an improvement of interventricular and intraventricular dyssynchrony after CRT, using the Fourier phase analysis of ERNA images [25–29].…”

Section: Introductionmentioning

confidence: 99%

Normality Index of Ventricular Contraction Based on a Statistical Model from FADS

Jiménez-Ángeles

Valdés-Cristerna

Vallejo

et al. 2013

Computational and Mathematical Methods in Medicine

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Radionuclide-based imaging is an alternative to evaluate ventricular function and synchrony and may be used as a tool for the identification of patients that could benefit from cardiac resynchronization therapy (CRT). In a previous work, we used Factor Analysis of Dynamic Structures (FADS) to analyze the contribution and spatial distribution of the 3 most significant factors (3-MSF) present in a dynamic series of equilibrium radionuclide angiography images. In this work, a probability density function model of the 3-MSF extracted from FADS for a control group is presented; also an index, based on the likelihood between the control group's contraction model and a sample of normal subjects is proposed. This normality index was compared with those computed for two cardiopathic populations, satisfying the clinical criteria to be considered as candidates for a CRT. The proposed normality index provides a measure, consistent with the phase analysis currently used in clinical environment, sensitive enough to show contraction differences between normal and abnormal groups, which suggests that it can be related to the degree of severity in the ventricular contraction dyssynchrony, and therefore shows promise as a follow-up procedure for patients under CRT.

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“…Indeed, in patients with dilated cardiomyopathy and wide QRS, Toussaint et al found that in the subgroup with LVEF of [ 15% at baseline, interventricular dyssynchrony was predictive of at least a 5% increase in LVEF at follow-up with a positive predictive value of 83%. 2 Kerwin et al also reported improvement in LVEF in patients with interventricular dyssynchrony at baseline who were implanted with BiV. 12 In another smallscale study, a threshold of 50°for interventricular contraction heterogeneity on RNA phase analysis correlated with symptoms improvement after LV pacing 13 and the decrease in the interventricular contraction delay was the most predictive parameter.…”

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confidence: 98%

“…Even if echocardiography is widely available, inexpensive and non-radiative, RNA is more reproducible, notably to quantify ventricular synchronization. 2 In contrast to echocardiography, RNA is not operator-dependent, relying on automated contour delineation to determine ventricular volumes, and Fourier phase analysis to provide contraction delays. RNA is also less limited than echocardiography by patients' morphology, specifically in female and obese patients.…”

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confidence: 99%